Intratubular hemoglobin casts in hemolysis-associated acute kidney injury

Mazdak Khalighi, Kammi J. Henriksen, Anthony Chang, Shane M. Meehan

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Kidney injury is a complication of intravascular hemolysis associated with many forms of hemolytic disease. Reports of kidney biopsy findings in patients with hemolysis-related kidney injury have focused primarily on the accumulation of hemosiderin pigment within proximal tubular epithelial cells (hemosiderosis), a feature of chronic hemolysis. The nephrotoxic effects of hemoglobin include direct cytotoxicity to tubular cells, but hemoglobin also can precipitate in distal nephron segments, forming obstructive casts. We present a case of hemolysis-associated tubular injury, characterized by acute onset of intravascular hemolysis followed by acute kidney injury with acute tubular injury and abundant intratubular casts containing hemoglobin.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume65
Issue number2
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Hemolysis
Acute Kidney Injury
Hemoglobins
Wounds and Injuries
Kidney
Hemosiderosis
Hemosiderin
Nephrons
Epithelial Cells
Biopsy

Keywords

  • Acute kidney injury (AKI)
  • acute tubular
  • biopsy acute
  • casts intravascular
  • hemolysis renal
  • injury hemoglobin
  • tubular necrosis

ASJC Scopus subject areas

  • Nephrology

Cite this

Intratubular hemoglobin casts in hemolysis-associated acute kidney injury. / Khalighi, Mazdak; Henriksen, Kammi J.; Chang, Anthony; Meehan, Shane M.

In: American Journal of Kidney Diseases, Vol. 65, No. 2, 01.01.2015, p. 337-341.

Research output: Contribution to journalArticle

Khalighi, Mazdak ; Henriksen, Kammi J. ; Chang, Anthony ; Meehan, Shane M. / Intratubular hemoglobin casts in hemolysis-associated acute kidney injury. In: American Journal of Kidney Diseases. 2015 ; Vol. 65, No. 2. pp. 337-341.
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