Abstract
Kidney injury is a complication of intravascular hemolysis associated with many forms of hemolytic disease. Reports of kidney biopsy findings in patients with hemolysis-related kidney injury have focused primarily on the accumulation of hemosiderin pigment within proximal tubular epithelial cells (hemosiderosis), a feature of chronic hemolysis. The nephrotoxic effects of hemoglobin include direct cytotoxicity to tubular cells, but hemoglobin also can precipitate in distal nephron segments, forming obstructive casts. We present a case of hemolysis-associated tubular injury, characterized by acute onset of intravascular hemolysis followed by acute kidney injury with acute tubular injury and abundant intratubular casts containing hemoglobin.
Original language | English (US) |
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Pages (from-to) | 337-341 |
Number of pages | 5 |
Journal | American Journal of Kidney Diseases |
Volume | 65 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2015 |
Keywords
- Acute kidney injury (AKI)
- acute tubular
- biopsy acute
- casts intravascular
- hemolysis renal
- injury hemoglobin
- tubular necrosis
ASJC Scopus subject areas
- Nephrology