Intrapancreatic accessory spleen: Mimic of pancreatic endocrine tumor diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy

Andrew M. Schreiner, Atiya Mansoor, Douglas O. Faigel, Terry Morgan

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Intrapancreatic accessory spleen forms a well-defined nodule within the tail of the pancreas and is commonly mistaken by imaging studies as a neuroendocrine tumor. We report three cases of intrapancreatic accessory spleen diagnosed by endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) biopsy. Imaging studies showed well-circumscribed nodules in the tail of the pancreas. Two lesions were clinically suspicious for pancreatic neuroendocrine tumors and one appeared to be a cyst. EUS-guided FNA revealed predominantly small lymphocytes with a subset of histiocytes, conspicuous eosinophils, and plasma cells. There was also characteristic CD8 positive immunostaining of endothelial cells in cell block sections. We report the first series of accessory spleen in the pancreas diagnosed by EUS-guided FNA with the aid of CD8 immunostaining of splenic sinus endothelial cells.

Original languageEnglish (US)
Pages (from-to)262-265
Number of pages4
JournalDiagnostic Cytopathology
Volume36
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

Endoscopic Ultrasound-Guided Fine Needle Aspiration
Fine Needle Biopsy
Pancreas
Spleen
Neuroendocrine Tumors
Endothelial Cells
Neoplasms
Histiocytes
Plasma Cells
Eosinophils
Cysts
Lymphocytes
tebufenozide

Keywords

  • Accessory spleen
  • Endoscopic ultrasound-guided fine-needle aspiration biopsy
  • Lymphoepithelial cyst
  • Neuroendocrine tumor
  • Pancreas

ASJC Scopus subject areas

  • Anatomy

Cite this

Intrapancreatic accessory spleen : Mimic of pancreatic endocrine tumor diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy. / Schreiner, Andrew M.; Mansoor, Atiya; Faigel, Douglas O.; Morgan, Terry.

In: Diagnostic Cytopathology, Vol. 36, No. 4, 04.2008, p. 262-265.

Research output: Contribution to journalArticle

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