Intraoperative radiation therapy in the multimodality approach to hepatobiliary tract cancer

Charles R. Thomas, Hollis W. Merrick

Research output: Contribution to journalReview article

Abstract

IOERT is a reasonable option to consider in patients who have biliary tract cancers above AJCC or Bismuth stage I disease. Inherent resistance of biliary tract cancer cells to ionizing radiation would indicate that IOERT alone would not eradicate most of the tumor clonagen. EBRT (either preoperatively or postoperatively) should be used in combination with IOERT at experienced institutions that have access to both modalities. The single IOERT dose ranges are 10 to 20 Gy [55,67], whereas the EBRT dose ranges from 45 to 50 Gy in 25 to 28 fractions [67]. The most common energy level used is 8 MeV or less. In addition, IOERT port sizes of less than 6 cm in diameter, and often 4 cm or less, are recommended. Finally, intraoperative reconstruction of severely damaged blood vessels may decrease the clinical manifestation of radiation-induced injury to vessels [68].

Original languageEnglish (US)
Pages (from-to)979-992
Number of pages14
JournalSurgical Oncology Clinics of North America
Volume12
Issue number4
DOIs
StatePublished - Oct 2003

ASJC Scopus subject areas

  • Surgery
  • Oncology

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