Intraocular inflammation and systemic immune-mediated diseases

Justine R. Smith, James T. Rosenbaum

Research output: Contribution to journalReview articlepeer-review


Certain forms of uveitis, or intraocular inflammation, occur in association with systemic immune-mediated diseases. The specific location of the inflammation within the eye is often helpful in diagnosing an associated systemic disease, but it also provides clues to the pathogenic mechanisms of the ocular and systemic pathology. In this review we consider the most common uveitis-systemic disease associations. We describe clinical aspects of these diseases and discuss current concepts in relation to the pathogenesis of the ocular inflammation. By clarifying the basic mechanisms operating in these conditions, it may be possible to design disease-specific therapies to manage the ocular inflammation, as well as the associated systemic disease.

Original languageEnglish (US)
Pages (from-to)378-384
Number of pages7
JournalCurrent Immunology Reviews
Issue number3
StatePublished - Aug 2011


  • Clinical features
  • Pathogenesis
  • Systemic disease
  • Uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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