As a model for the chemical effects of the decay of radioiodine in iodinated proteins, [131I-14C]-o-iodophenol has been synthesized and the iodine-131 allowed to decay in aqueous solutions containing various phenolic additives. Reference samples were also studied in which the radioiodine was added as 131I- to [127I-14C]-o-iodophenol. Similar products were observed from hydrolytic deiodination of the o-iodophenol, radiolysis of the molecule by external radiation, and as a result of decay of organically bound iodine-131. A mechanism is proposed in which decay of the iodine in [131I-14C]-o-iodophenol leaves a carbonium ion [C6H4(OH)+] which in solution reacts to form catechol. It is postulated that the other products formed are oxidation products of catechol.
ASJC Scopus subject areas
- Colloid and Surface Chemistry