Intramembranous solute and water fluxes during high intramembranous absorption rates in fetal sheep with and without lung liquid diversion

Katherine M. Gesteland, Debra Anderson, Lowell Davis, Patricia Robertson, J. Job Faber, Robert A. Brace

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective: To examine mechanisms that mediate increased intramembranous solute and water absorption. Study Design: Intramembranous solute and water fluxes were measured in fetal sheep under basal conditions and after intraamniotic infusion of lactated Ringer's solution of 4 L/d for 3 days with and without lung liquid diversion. Results: Intramembranous sodium, potassium, chloride, calcium, glucose, and lactate fluxes increased 2.5- to 7.9-fold, were linearly related to volume fluxes (r = 0.83-0.99), and were unaffected by lung liquid. All clearance rates, except that of lactate, increased to equal the intramembranous volume absorption rate during infusion. Conclusion: Under basal conditions, passive diffusion makes a minor and bulk flow a major contribution to intramembranous solute absorption. During high absorption rates, the increase in solute absorption above basal levels appears to be due entirely to bulk flow and is unaffected by lung liquid. The increased bulk flow is consistent with vesicular transcytosis.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume201
Issue number1
DOIs
StatePublished - Jul 2009

Fingerprint

Sheep
Lung
Water
Transcytosis
Potassium Chloride
Sodium Chloride
Lactic Acid
Glucose

Keywords

  • bulk flow
  • fetal sheep
  • intramembranous water and solute absorption
  • passive diffusion
  • vesicular transport

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Intramembranous solute and water fluxes during high intramembranous absorption rates in fetal sheep with and without lung liquid diversion. / Gesteland, Katherine M.; Anderson, Debra; Davis, Lowell; Robertson, Patricia; Faber, J. Job; Brace, Robert A.

In: American Journal of Obstetrics and Gynecology, Vol. 201, No. 1, 07.2009.

Research output: Contribution to journalArticle

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