TY - JOUR
T1 - Intraglomerular hypertension
T2 - Implications and drug treatment
AU - Anderson, S.
AU - Brenner, B. M.
PY - 1988
Y1 - 1988
N2 - Systemic hypertension is both cause and consequence of progressive renal disease. Recent experimental studies indicate that systemic and glomerular capillary hypertension are not necessarily accompaniments, and that therapeutic interventions may affect systemic and glomerular pressures independently. Therapeutic interventions that control glomerular capillary hypertension protect against progressive renal injury, even in the presence of continued systemic hypertension. Conversely, therapy that controls systemic but not glomerular hypertension does not protect the kidney from continuing damage. Thus, control of intraglomerular hypertension is necessary if antihypertensive therapy is to be effective in preventing progression of renal injury.
AB - Systemic hypertension is both cause and consequence of progressive renal disease. Recent experimental studies indicate that systemic and glomerular capillary hypertension are not necessarily accompaniments, and that therapeutic interventions may affect systemic and glomerular pressures independently. Therapeutic interventions that control glomerular capillary hypertension protect against progressive renal injury, even in the presence of continued systemic hypertension. Conversely, therapy that controls systemic but not glomerular hypertension does not protect the kidney from continuing damage. Thus, control of intraglomerular hypertension is necessary if antihypertensive therapy is to be effective in preventing progression of renal injury.
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U2 - 10.1146/annurev.me.39.020188.001331
DO - 10.1146/annurev.me.39.020188.001331
M3 - Review article
C2 - 3285775
AN - SCOPUS:0024217372
SN - 0066-4219
VL - 39
SP - 243
EP - 253
JO - Annual review of medicine
JF - Annual review of medicine
ER -