Intraglomerular hypertension: Implications and drug treatment

S. Anderson, B. M. Brenner

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Systemic hypertension is both cause and consequence of progressive renal disease. Recent experimental studies indicate that systemic and glomerular capillary hypertension are not necessarily accompaniments, and that therapeutic interventions may affect systemic and glomerular pressures independently. Therapeutic interventions that control glomerular capillary hypertension protect against progressive renal injury, even in the presence of continued systemic hypertension. Conversely, therapy that controls systemic but not glomerular hypertension does not protect the kidney from continuing damage. Thus, control of intraglomerular hypertension is necessary if antihypertensive therapy is to be effective in preventing progression of renal injury.

Original languageEnglish (US)
Pages (from-to)243-253
Number of pages11
JournalAnnual review of medicine
Volume39
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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