Intracranial pressure effects of dexmedetomidine in rabbits

Mark Zornow, M. S. Scheller, P. B. Sheehan, M. A P Strnat, M. Matsumoto

Research output: Contribution to journalArticle

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Abstract

The α2-adrenergic receptor agonist dexmedetomidine produces an anesthetic state in a variety of species. Although its effects on cerebral blood flow and the electroencephalogram have been investigated, the effect of this drug on intracranial pressure (IGP) has not been reported previously. Dexmedetomidine therefore as intravenously administered to 24 New Zealand white rabbits that had been anesthetized with halothane and mechanically ventilated to maintain a constant arterial CO2 tension (PaCO2) between 34 and 39 mm Hg. After placement of an arterial catheter and ventricular cannula, baseline measurements of monitored variables, including heart rate, mean arterial blood pressure, ICP, end-tidal CO2, body temperature, and arterial blood gases, were recorded. Dexmedetomidine (20, 80, or 320 μg/kg IV) or saline solution was then infused over a 10-min period. The ICP transiently decreased by 31% in the 20-μg/kg group (from a mean value of 9.4 ± 1.3 [SEM] to 6.5 ± 1.0 mm Hg, P <0.05). In the 320-μg/kg group, ICP remained unchanged over the course of the study despite a significant increase in arterial blood pressure (32 mm Hg). The effects of dexmedetomidine on ICP were next investigated in the presence of intracranial hypertension produced by a cryogenic lesion (mean baseline ICP 16.8 mm Hg). In addition to the previously monitored variables, sagittal sinus blood flow was measured by the hydrogen clearance technique before and after the administration of dexmedetomidine (320 μg/kg IV). In these experiments, dexmedetomidine was associated with a 14% decrease in sagittal sinus blood flow that was not statistically significant. There was no change in ICP after the administration of dexmedetomidine in this model of intracranial hypertension. From these studies, we conclude that dexmedetomidine has minimal effects on ICP in halothane-anesthetized rabbits.

Original languageEnglish (US)
Pages (from-to)232-237
Number of pages6
JournalAnesthesia and Analgesia
Volume75
Issue number2
StatePublished - 1992
Externally publishedYes

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Dexmedetomidine
Intracranial Pressure
Rabbits
Arterial Pressure
Intracranial Hypertension
Halothane
Cerebrovascular Circulation
Adrenergic Agonists
Body Temperature
Sodium Chloride
Anesthetics
Electroencephalography
Hydrogen
Catheters
Heart Rate
Gases

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Zornow, M., Scheller, M. S., Sheehan, P. B., Strnat, M. A. P., & Matsumoto, M. (1992). Intracranial pressure effects of dexmedetomidine in rabbits. Anesthesia and Analgesia, 75(2), 232-237.

Intracranial pressure effects of dexmedetomidine in rabbits. / Zornow, Mark; Scheller, M. S.; Sheehan, P. B.; Strnat, M. A P; Matsumoto, M.

In: Anesthesia and Analgesia, Vol. 75, No. 2, 1992, p. 232-237.

Research output: Contribution to journalArticle

Zornow, M, Scheller, MS, Sheehan, PB, Strnat, MAP & Matsumoto, M 1992, 'Intracranial pressure effects of dexmedetomidine in rabbits', Anesthesia and Analgesia, vol. 75, no. 2, pp. 232-237.
Zornow M, Scheller MS, Sheehan PB, Strnat MAP, Matsumoto M. Intracranial pressure effects of dexmedetomidine in rabbits. Anesthesia and Analgesia. 1992;75(2):232-237.
Zornow, Mark ; Scheller, M. S. ; Sheehan, P. B. ; Strnat, M. A P ; Matsumoto, M. / Intracranial pressure effects of dexmedetomidine in rabbits. In: Anesthesia and Analgesia. 1992 ; Vol. 75, No. 2. pp. 232-237.
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