Intracellular signal transduction pathways as targets for neurotoxicants

L. G. Costa, Marina Guizzetti, H. Lu, F. Bordi, A. Vitalone, B. Tita, M. Palmery, P. Valeri, B. Silvestrini

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The multiple cascades of signal transduction pathways that lead from receptors on the cell membrane to the nucleus, thus translating extracellular signals into changes in gene expression, may represent important targets for neurotoxic compounds. Among the biochemical steps and pathways that have been investigated are the metabolism of cyclic nucleotides, the formation of nitric oxide, the metabolism of membrane phospholipids, the activation of a multitude of protein kinases and the induction of transcription factors. This brief review will focus on the interactions of three known neurotoxicants, lead, ethanol and polychlorinated biphenyls, with signal transduction pathways, particularly the family of protein kinase C isozymes, and discusses how such effects may be involved in their neurotoxicity.

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalToxicology
Volume160
Issue number1-3
DOIs
Publication statusPublished - Mar 7 2001
Externally publishedYes

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Keywords

  • Intracellular signal transduction pathways
  • Neurotoxicants

ASJC Scopus subject areas

  • Toxicology

Cite this

Costa, L. G., Guizzetti, M., Lu, H., Bordi, F., Vitalone, A., Tita, B., ... Silvestrini, B. (2001). Intracellular signal transduction pathways as targets for neurotoxicants. Toxicology, 160(1-3), 19-26. https://doi.org/10.1016/S0300-483X(00)00435-2