Intracellular signal transduction pathways as targets for neurotoxicants

L. G. Costa, Marina Guizzetti, H. Lu, F. Bordi, A. Vitalone, B. Tita, M. Palmery, P. Valeri, B. Silvestrini

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The multiple cascades of signal transduction pathways that lead from receptors on the cell membrane to the nucleus, thus translating extracellular signals into changes in gene expression, may represent important targets for neurotoxic compounds. Among the biochemical steps and pathways that have been investigated are the metabolism of cyclic nucleotides, the formation of nitric oxide, the metabolism of membrane phospholipids, the activation of a multitude of protein kinases and the induction of transcription factors. This brief review will focus on the interactions of three known neurotoxicants, lead, ethanol and polychlorinated biphenyls, with signal transduction pathways, particularly the family of protein kinase C isozymes, and discusses how such effects may be involved in their neurotoxicity.

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalToxicology
Volume160
Issue number1-3
DOIs
StatePublished - Mar 7 2001
Externally publishedYes

Fingerprint

Signal transduction
Metabolism
Signal Transduction
Cyclic Nucleotides
Polychlorinated Biphenyls
Cell membranes
Gene expression
Protein Kinases
Protein Kinase C
Isoenzymes
Phospholipids
Nitric Oxide
Ethanol
Transcription Factors
Chemical activation
Cell Membrane
Membranes
Gene Expression
Lead

Keywords

  • Intracellular signal transduction pathways
  • Neurotoxicants

ASJC Scopus subject areas

  • Toxicology

Cite this

Costa, L. G., Guizzetti, M., Lu, H., Bordi, F., Vitalone, A., Tita, B., ... Silvestrini, B. (2001). Intracellular signal transduction pathways as targets for neurotoxicants. Toxicology, 160(1-3), 19-26. https://doi.org/10.1016/S0300-483X(00)00435-2

Intracellular signal transduction pathways as targets for neurotoxicants. / Costa, L. G.; Guizzetti, Marina; Lu, H.; Bordi, F.; Vitalone, A.; Tita, B.; Palmery, M.; Valeri, P.; Silvestrini, B.

In: Toxicology, Vol. 160, No. 1-3, 07.03.2001, p. 19-26.

Research output: Contribution to journalArticle

Costa, LG, Guizzetti, M, Lu, H, Bordi, F, Vitalone, A, Tita, B, Palmery, M, Valeri, P & Silvestrini, B 2001, 'Intracellular signal transduction pathways as targets for neurotoxicants', Toxicology, vol. 160, no. 1-3, pp. 19-26. https://doi.org/10.1016/S0300-483X(00)00435-2
Costa, L. G. ; Guizzetti, Marina ; Lu, H. ; Bordi, F. ; Vitalone, A. ; Tita, B. ; Palmery, M. ; Valeri, P. ; Silvestrini, B. / Intracellular signal transduction pathways as targets for neurotoxicants. In: Toxicology. 2001 ; Vol. 160, No. 1-3. pp. 19-26.
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