TY - JOUR
T1 - Intracellular signal transduction pathways as targets for neurotoxicants
AU - Costa, L. G.
AU - Guizzetti, M.
AU - Lu, H.
AU - Bordi, F.
AU - Vitalone, A.
AU - Tita, B.
AU - Palmery, M.
AU - Valeri, P.
AU - Silvestrini, B.
N1 - Funding Information:
Research by the authors was supported by grant from the National Institutes of Health (ES-7033, AA-8154), the European Union (QLK4-1999-01562) and the University of Roma.
PY - 2001/3/7
Y1 - 2001/3/7
N2 - The multiple cascades of signal transduction pathways that lead from receptors on the cell membrane to the nucleus, thus translating extracellular signals into changes in gene expression, may represent important targets for neurotoxic compounds. Among the biochemical steps and pathways that have been investigated are the metabolism of cyclic nucleotides, the formation of nitric oxide, the metabolism of membrane phospholipids, the activation of a multitude of protein kinases and the induction of transcription factors. This brief review will focus on the interactions of three known neurotoxicants, lead, ethanol and polychlorinated biphenyls, with signal transduction pathways, particularly the family of protein kinase C isozymes, and discusses how such effects may be involved in their neurotoxicity.
AB - The multiple cascades of signal transduction pathways that lead from receptors on the cell membrane to the nucleus, thus translating extracellular signals into changes in gene expression, may represent important targets for neurotoxic compounds. Among the biochemical steps and pathways that have been investigated are the metabolism of cyclic nucleotides, the formation of nitric oxide, the metabolism of membrane phospholipids, the activation of a multitude of protein kinases and the induction of transcription factors. This brief review will focus on the interactions of three known neurotoxicants, lead, ethanol and polychlorinated biphenyls, with signal transduction pathways, particularly the family of protein kinase C isozymes, and discusses how such effects may be involved in their neurotoxicity.
KW - Intracellular signal transduction pathways
KW - Neurotoxicants
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U2 - 10.1016/S0300-483X(00)00435-2
DO - 10.1016/S0300-483X(00)00435-2
M3 - Article
C2 - 11246120
AN - SCOPUS:0035819907
SN - 0300-483X
VL - 160
SP - 19
EP - 26
JO - Toxicology
JF - Toxicology
IS - 1-3
ER -