Intra-operative correction of acidosis, coagulopathy and hypothermia in combat casualties with severe haemorrhagic shock

J. J. Morrison, James Ross, H. Poon, M. J. Midwinter, J. O. Jansen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We assessed acidosis, coagulopathy and hypothermia, before and after surgery in 51 combat troops operated on for severe blast injury. Patients were transfused a median (IQR [range]) of 27 (17-38 [5-84]) units of red cell concentrate, 27 (16-38 [4-83]) units of plasma, 2.0 (0.5-3.5 [0-13.0]) units of cryoprecipitate and 4 (2-6 [0-17]) pools of platelets. The pH, base excess, prothrombin time and temperature increased: from 7.19 (7.10-7.29 [6.50-7.49]) to 7.45 (7.40-7.51 [7.15-7.62]); from -9.0 (-13.5 to -4.5 [-28 to -2]) mmol.l -1 to 4.5 (1.0-8.0 [-7 to +11]) mmol.l-1; from 18 (15-21 [9-24]) s to 14 (11-18 [9-21]) s; and from 36.1 (35.1-37.1 [33.0-38.1]) °C to 37.4 (37.0-37.9 [36.0-38.0]) °C, respectively. Contemporary intra-operative resuscitation strategies can normalise the physiological derangements caused by haemorrhagic shock.

Original languageEnglish (US)
Pages (from-to)846-850
Number of pages5
JournalAnaesthesia
Volume68
Issue number8
DOIs
StatePublished - Aug 2013
Externally publishedYes

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Blast Injuries
Hemorrhagic Shock
Prothrombin Time
Acidosis
Hypothermia
Resuscitation
Blood Platelets
Temperature

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Intra-operative correction of acidosis, coagulopathy and hypothermia in combat casualties with severe haemorrhagic shock. / Morrison, J. J.; Ross, James; Poon, H.; Midwinter, M. J.; Jansen, J. O.

In: Anaesthesia, Vol. 68, No. 8, 08.2013, p. 846-850.

Research output: Contribution to journalArticle

Morrison, J. J. ; Ross, James ; Poon, H. ; Midwinter, M. J. ; Jansen, J. O. / Intra-operative correction of acidosis, coagulopathy and hypothermia in combat casualties with severe haemorrhagic shock. In: Anaesthesia. 2013 ; Vol. 68, No. 8. pp. 846-850.
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