Intra-hematopoietic cell fusion as a source of somatic variation in the hematopoietic system

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cell fusion plays a well-recognized, physiological role during development. Bone-marrow-derived hematopoietic cells have been shown to fuse with non-hematopoietic cells in a wide variety of tissues. Some organs appear to resolve the changes in ploidy status, generating functional and mitotically-competent events. However, cell fusion exclusively involving hematopoietic cells has not been reported. Indeed, genomic copy number variation in highly replicative hematopoietic cells is widely considered a hallmark of malignant transformation. Here we show that cell fusion occurs between cells of the hematopoietic system under injury as well as non-injury conditions. Experiments reveal the acquisition of genetic markers in fusion products, their tractable maintenance during hematopoietic differentiation and long-term persistence after serial transplantation. Fusion events were identified in clonogenic progenitors as well as differentiated myeloid and lymphoid cells. These observations provide a new experimental model for the study of non-pathogenic somatic diversity in the hematopoietic system.

Original languageEnglish (US)
Pages (from-to)2837-2843
Number of pages7
JournalJournal of Cell Science
Volume125
Issue number12
DOIs
StatePublished - Jun 15 2012

Fingerprint

Hematopoietic System
Cell Fusion
Ploidies
Myeloid Cells
Genetic Markers
Theoretical Models
Transplantation
Bone Marrow
Maintenance
Lymphocytes
Wounds and Injuries

Keywords

  • Copy number variation
  • Intra-hematopoietic cell fusion
  • Somatic diversity

ASJC Scopus subject areas

  • Cell Biology

Cite this

Intra-hematopoietic cell fusion as a source of somatic variation in the hematopoietic system. / Skinner, Amy; Grompe, Markus; Kurre, Peter.

In: Journal of Cell Science, Vol. 125, No. 12, 15.06.2012, p. 2837-2843.

Research output: Contribution to journalArticle

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