Intra-arterial urokinase for treatment of retrograde thrombosis following resection of an arteriovenous malformation. Case report

E. P. Sipos, Jeffrey Kirsch, H. J W Nauta, G. Debrun, J. A. Ulatowski, W. R. Bell

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Retrograde thrombosis of feeding arteries is a potentially catastrophic complication occasionally reported following resection of arteriovenous malformations (AVM's). No successful therapy for this condition, which causes postoperative stroke, has previously been reported. A case of retrograde thrombosis of the left middle cerebral artery immediately following resection of a parietal AVM is reported in a patient with a retained intra-arterial catheter from preoperative embolization. The administration of urokinase within 4 hours of surgery resulted in dramatic clinical and angiographic improvement without hemorrhagic complications. While urokinase is considered highly experimental in this setting, this case demonstrates that thrombolytic agents should be viewed as therapeutic options worthy of further investigation.

Original languageEnglish (US)
Pages (from-to)1004-1007
Number of pages4
JournalJournal of Neurosurgery
Volume76
Issue number6
StatePublished - 1992
Externally publishedYes

Fingerprint

Arteriovenous Malformations
Urokinase-Type Plasminogen Activator
Thrombosis
Fibrinolytic Agents
Middle Cerebral Artery Infarction
Catheters
Arteries
Stroke
Therapeutics

Keywords

  • arteriovenous malformation
  • embolization
  • retrograde thrombosis
  • thrombolytic therapy
  • urokinase

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Intra-arterial urokinase for treatment of retrograde thrombosis following resection of an arteriovenous malformation. Case report. / Sipos, E. P.; Kirsch, Jeffrey; Nauta, H. J W; Debrun, G.; Ulatowski, J. A.; Bell, W. R.

In: Journal of Neurosurgery, Vol. 76, No. 6, 1992, p. 1004-1007.

Research output: Contribution to journalArticle

Sipos, E. P. ; Kirsch, Jeffrey ; Nauta, H. J W ; Debrun, G. ; Ulatowski, J. A. ; Bell, W. R. / Intra-arterial urokinase for treatment of retrograde thrombosis following resection of an arteriovenous malformation. Case report. In: Journal of Neurosurgery. 1992 ; Vol. 76, No. 6. pp. 1004-1007.
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