TY - JOUR
T1 - Intra-abdominal fat accumulation is greatest at younger ages in Japanese-American adults
AU - Lee, Christine G.
AU - Fujimoto, Wilfred Y.
AU - Brunzell, John D.
AU - Kahn, Steven E.
AU - McNeely, Marguerite J.
AU - Leonetti, Donna L.
AU - Boyko, Edward J.
N1 - Funding Information:
This work was supported by National Institutes of Health Grants DK-31170 , HL-49293 , and DK-02654 ; by facilities and services provided by the Diabetes and Endocrinology Research Center (DK-17047), Clinical Nutrition Research Unit (DK-35816), and the General Clinical Research Center (RR-00037) at the University of Washington, and by the Medical Research Service of the Department of Veterans Affairs. These data have been presented at the following meetings: American Federation for Medical Research Western Regional Meeting, Carmel, CA, January 2009 and 11th Symposium of the International Diabetes Epidemiology Group, Montreal, CAN, October 2009.
PY - 2010/7
Y1 - 2010/7
N2 - Aims: We evaluated whether changes over 10-11 years in weight, subcutaneous abdominal fat (SQAF), and intra-abdominal fat (IAF) differ by age and contrasted age-related adiposity changes by gender. Methods: This is a prospective cohort study of non-diabetic, Japanese-American men and women aged 34-74 years. IAF and SQAF were measured by CT scan at baseline and 10-11-year follow-up visits. Results: The youngest participants gained the most weight, SQAF and IAF over 10-11 years. Older age at baseline was associated with significantly less change in weight (β-coefficient: -0.19, 95% CI -0.22, -0.15), SQAF (β-coefficient: -0.07, 95% CI -0.11, -0.02) and IAF (β-coefficient: -0.74, 95% CI -1.03, -0.45) that persisted even after adjustments for sex, smoking, caloric intake, adiposity at baseline, and change in physical activity. Age was positively correlated with change in SQAF (β-coefficient: 0.14, 95% CI 0.10, 0.18) and IAF (β-coefficient: 0.51, 95% CI 0.21, 0.81) in separate models after further adjustment for weight change. Gender did not alter the associations between adiposity change and age. Conclusions: Men and women gained the greatest absolute amount of weight, SQAF, and IAF at younger ages; however, older adults with comparable weight changes had relatively greater fat accumulation within IAF and SQAF depots.
AB - Aims: We evaluated whether changes over 10-11 years in weight, subcutaneous abdominal fat (SQAF), and intra-abdominal fat (IAF) differ by age and contrasted age-related adiposity changes by gender. Methods: This is a prospective cohort study of non-diabetic, Japanese-American men and women aged 34-74 years. IAF and SQAF were measured by CT scan at baseline and 10-11-year follow-up visits. Results: The youngest participants gained the most weight, SQAF and IAF over 10-11 years. Older age at baseline was associated with significantly less change in weight (β-coefficient: -0.19, 95% CI -0.22, -0.15), SQAF (β-coefficient: -0.07, 95% CI -0.11, -0.02) and IAF (β-coefficient: -0.74, 95% CI -1.03, -0.45) that persisted even after adjustments for sex, smoking, caloric intake, adiposity at baseline, and change in physical activity. Age was positively correlated with change in SQAF (β-coefficient: 0.14, 95% CI 0.10, 0.18) and IAF (β-coefficient: 0.51, 95% CI 0.21, 0.81) in separate models after further adjustment for weight change. Gender did not alter the associations between adiposity change and age. Conclusions: Men and women gained the greatest absolute amount of weight, SQAF, and IAF at younger ages; however, older adults with comparable weight changes had relatively greater fat accumulation within IAF and SQAF depots.
KW - Adiposity
KW - Aging
KW - Intra-abdominal fat
KW - Japanese-American
KW - Longitudinal
UR - http://www.scopus.com/inward/record.url?scp=77953811057&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953811057&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2010.03.006
DO - 10.1016/j.diabres.2010.03.006
M3 - Article
C2 - 20392506
AN - SCOPUS:77953811057
VL - 89
SP - 58
EP - 64
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
IS - 1
ER -