Intra-abdominal fat accumulation is greatest at younger ages in Japanese-American adults

Christine Lee, Wilfred Y. Fujimoto, John D. Brunzell, Steven E. Kahn, Marguerite J. McNeely, Donna L. Leonetti, Edward J. Boyko

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Aims: We evaluated whether changes over 10-11 years in weight, subcutaneous abdominal fat (SQAF), and intra-abdominal fat (IAF) differ by age and contrasted age-related adiposity changes by gender. Methods: This is a prospective cohort study of non-diabetic, Japanese-American men and women aged 34-74 years. IAF and SQAF were measured by CT scan at baseline and 10-11-year follow-up visits. Results: The youngest participants gained the most weight, SQAF and IAF over 10-11 years. Older age at baseline was associated with significantly less change in weight (β-coefficient: -0.19, 95% CI -0.22, -0.15), SQAF (β-coefficient: -0.07, 95% CI -0.11, -0.02) and IAF (β-coefficient: -0.74, 95% CI -1.03, -0.45) that persisted even after adjustments for sex, smoking, caloric intake, adiposity at baseline, and change in physical activity. Age was positively correlated with change in SQAF (β-coefficient: 0.14, 95% CI 0.10, 0.18) and IAF (β-coefficient: 0.51, 95% CI 0.21, 0.81) in separate models after further adjustment for weight change. Gender did not alter the associations between adiposity change and age. Conclusions: Men and women gained the greatest absolute amount of weight, SQAF, and IAF at younger ages; however, older adults with comparable weight changes had relatively greater fat accumulation within IAF and SQAF depots.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume89
Issue number1
DOIs
StatePublished - Jul 2010

Fingerprint

Asian Americans
Intra-Abdominal Fat
Weights and Measures
Adiposity
Abdominal Subcutaneous Fat
Energy Intake
Cohort Studies
Smoking
Fats
Prospective Studies
Exercise

Keywords

  • Adiposity
  • Aging
  • Intra-abdominal fat
  • Japanese-American
  • Longitudinal

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology
  • Medicine(all)

Cite this

Lee, C., Fujimoto, W. Y., Brunzell, J. D., Kahn, S. E., McNeely, M. J., Leonetti, D. L., & Boyko, E. J. (2010). Intra-abdominal fat accumulation is greatest at younger ages in Japanese-American adults. Diabetes Research and Clinical Practice, 89(1), 58-64. https://doi.org/10.1016/j.diabres.2010.03.006

Intra-abdominal fat accumulation is greatest at younger ages in Japanese-American adults. / Lee, Christine; Fujimoto, Wilfred Y.; Brunzell, John D.; Kahn, Steven E.; McNeely, Marguerite J.; Leonetti, Donna L.; Boyko, Edward J.

In: Diabetes Research and Clinical Practice, Vol. 89, No. 1, 07.2010, p. 58-64.

Research output: Contribution to journalArticle

Lee, C, Fujimoto, WY, Brunzell, JD, Kahn, SE, McNeely, MJ, Leonetti, DL & Boyko, EJ 2010, 'Intra-abdominal fat accumulation is greatest at younger ages in Japanese-American adults', Diabetes Research and Clinical Practice, vol. 89, no. 1, pp. 58-64. https://doi.org/10.1016/j.diabres.2010.03.006
Lee, Christine ; Fujimoto, Wilfred Y. ; Brunzell, John D. ; Kahn, Steven E. ; McNeely, Marguerite J. ; Leonetti, Donna L. ; Boyko, Edward J. / Intra-abdominal fat accumulation is greatest at younger ages in Japanese-American adults. In: Diabetes Research and Clinical Practice. 2010 ; Vol. 89, No. 1. pp. 58-64.
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abstract = "Aims: We evaluated whether changes over 10-11 years in weight, subcutaneous abdominal fat (SQAF), and intra-abdominal fat (IAF) differ by age and contrasted age-related adiposity changes by gender. Methods: This is a prospective cohort study of non-diabetic, Japanese-American men and women aged 34-74 years. IAF and SQAF were measured by CT scan at baseline and 10-11-year follow-up visits. Results: The youngest participants gained the most weight, SQAF and IAF over 10-11 years. Older age at baseline was associated with significantly less change in weight (β-coefficient: -0.19, 95{\%} CI -0.22, -0.15), SQAF (β-coefficient: -0.07, 95{\%} CI -0.11, -0.02) and IAF (β-coefficient: -0.74, 95{\%} CI -1.03, -0.45) that persisted even after adjustments for sex, smoking, caloric intake, adiposity at baseline, and change in physical activity. Age was positively correlated with change in SQAF (β-coefficient: 0.14, 95{\%} CI 0.10, 0.18) and IAF (β-coefficient: 0.51, 95{\%} CI 0.21, 0.81) in separate models after further adjustment for weight change. Gender did not alter the associations between adiposity change and age. Conclusions: Men and women gained the greatest absolute amount of weight, SQAF, and IAF at younger ages; however, older adults with comparable weight changes had relatively greater fat accumulation within IAF and SQAF depots.",
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AU - Leonetti, Donna L.

AU - Boyko, Edward J.

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