Intra-abdominal fat accumulation is greatest at younger ages in Japanese-American adults

Christine G. Lee, Wilfred Y. Fujimoto, John D. Brunzell, Steven E. Kahn, Marguerite J. McNeely, Donna L. Leonetti, Edward J. Boyko

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Aims: We evaluated whether changes over 10-11 years in weight, subcutaneous abdominal fat (SQAF), and intra-abdominal fat (IAF) differ by age and contrasted age-related adiposity changes by gender. Methods: This is a prospective cohort study of non-diabetic, Japanese-American men and women aged 34-74 years. IAF and SQAF were measured by CT scan at baseline and 10-11-year follow-up visits. Results: The youngest participants gained the most weight, SQAF and IAF over 10-11 years. Older age at baseline was associated with significantly less change in weight (β-coefficient: -0.19, 95% CI -0.22, -0.15), SQAF (β-coefficient: -0.07, 95% CI -0.11, -0.02) and IAF (β-coefficient: -0.74, 95% CI -1.03, -0.45) that persisted even after adjustments for sex, smoking, caloric intake, adiposity at baseline, and change in physical activity. Age was positively correlated with change in SQAF (β-coefficient: 0.14, 95% CI 0.10, 0.18) and IAF (β-coefficient: 0.51, 95% CI 0.21, 0.81) in separate models after further adjustment for weight change. Gender did not alter the associations between adiposity change and age. Conclusions: Men and women gained the greatest absolute amount of weight, SQAF, and IAF at younger ages; however, older adults with comparable weight changes had relatively greater fat accumulation within IAF and SQAF depots.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume89
Issue number1
DOIs
StatePublished - Jul 2010

Keywords

  • Adiposity
  • Aging
  • Intra-abdominal fat
  • Japanese-American
  • Longitudinal

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Lee, C. G., Fujimoto, W. Y., Brunzell, J. D., Kahn, S. E., McNeely, M. J., Leonetti, D. L., & Boyko, E. J. (2010). Intra-abdominal fat accumulation is greatest at younger ages in Japanese-American adults. Diabetes Research and Clinical Practice, 89(1), 58-64. https://doi.org/10.1016/j.diabres.2010.03.006