Abstract
Aims: We evaluated whether changes over 10-11 years in weight, subcutaneous abdominal fat (SQAF), and intra-abdominal fat (IAF) differ by age and contrasted age-related adiposity changes by gender. Methods: This is a prospective cohort study of non-diabetic, Japanese-American men and women aged 34-74 years. IAF and SQAF were measured by CT scan at baseline and 10-11-year follow-up visits. Results: The youngest participants gained the most weight, SQAF and IAF over 10-11 years. Older age at baseline was associated with significantly less change in weight (β-coefficient: -0.19, 95% CI -0.22, -0.15), SQAF (β-coefficient: -0.07, 95% CI -0.11, -0.02) and IAF (β-coefficient: -0.74, 95% CI -1.03, -0.45) that persisted even after adjustments for sex, smoking, caloric intake, adiposity at baseline, and change in physical activity. Age was positively correlated with change in SQAF (β-coefficient: 0.14, 95% CI 0.10, 0.18) and IAF (β-coefficient: 0.51, 95% CI 0.21, 0.81) in separate models after further adjustment for weight change. Gender did not alter the associations between adiposity change and age. Conclusions: Men and women gained the greatest absolute amount of weight, SQAF, and IAF at younger ages; however, older adults with comparable weight changes had relatively greater fat accumulation within IAF and SQAF depots.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 58-64 |
| Number of pages | 7 |
| Journal | Diabetes Research and Clinical Practice |
| Volume | 89 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 2010 |
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Keywords
- Adiposity
- Aging
- Intra-abdominal fat
- Japanese-American
- Longitudinal
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Internal Medicine
- Endocrinology
- Medicine(all)
Cite this
Intra-abdominal fat accumulation is greatest at younger ages in Japanese-American adults. / Lee, Christine; Fujimoto, Wilfred Y.; Brunzell, John D.; Kahn, Steven E.; McNeely, Marguerite J.; Leonetti, Donna L.; Boyko, Edward J.
In: Diabetes Research and Clinical Practice, Vol. 89, No. 1, 07.2010, p. 58-64.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intra-abdominal fat accumulation is greatest at younger ages in Japanese-American adults
AU - Lee, Christine
AU - Fujimoto, Wilfred Y.
AU - Brunzell, John D.
AU - Kahn, Steven E.
AU - McNeely, Marguerite J.
AU - Leonetti, Donna L.
AU - Boyko, Edward J.
PY - 2010/7
Y1 - 2010/7
N2 - Aims: We evaluated whether changes over 10-11 years in weight, subcutaneous abdominal fat (SQAF), and intra-abdominal fat (IAF) differ by age and contrasted age-related adiposity changes by gender. Methods: This is a prospective cohort study of non-diabetic, Japanese-American men and women aged 34-74 years. IAF and SQAF were measured by CT scan at baseline and 10-11-year follow-up visits. Results: The youngest participants gained the most weight, SQAF and IAF over 10-11 years. Older age at baseline was associated with significantly less change in weight (β-coefficient: -0.19, 95% CI -0.22, -0.15), SQAF (β-coefficient: -0.07, 95% CI -0.11, -0.02) and IAF (β-coefficient: -0.74, 95% CI -1.03, -0.45) that persisted even after adjustments for sex, smoking, caloric intake, adiposity at baseline, and change in physical activity. Age was positively correlated with change in SQAF (β-coefficient: 0.14, 95% CI 0.10, 0.18) and IAF (β-coefficient: 0.51, 95% CI 0.21, 0.81) in separate models after further adjustment for weight change. Gender did not alter the associations between adiposity change and age. Conclusions: Men and women gained the greatest absolute amount of weight, SQAF, and IAF at younger ages; however, older adults with comparable weight changes had relatively greater fat accumulation within IAF and SQAF depots.
AB - Aims: We evaluated whether changes over 10-11 years in weight, subcutaneous abdominal fat (SQAF), and intra-abdominal fat (IAF) differ by age and contrasted age-related adiposity changes by gender. Methods: This is a prospective cohort study of non-diabetic, Japanese-American men and women aged 34-74 years. IAF and SQAF were measured by CT scan at baseline and 10-11-year follow-up visits. Results: The youngest participants gained the most weight, SQAF and IAF over 10-11 years. Older age at baseline was associated with significantly less change in weight (β-coefficient: -0.19, 95% CI -0.22, -0.15), SQAF (β-coefficient: -0.07, 95% CI -0.11, -0.02) and IAF (β-coefficient: -0.74, 95% CI -1.03, -0.45) that persisted even after adjustments for sex, smoking, caloric intake, adiposity at baseline, and change in physical activity. Age was positively correlated with change in SQAF (β-coefficient: 0.14, 95% CI 0.10, 0.18) and IAF (β-coefficient: 0.51, 95% CI 0.21, 0.81) in separate models after further adjustment for weight change. Gender did not alter the associations between adiposity change and age. Conclusions: Men and women gained the greatest absolute amount of weight, SQAF, and IAF at younger ages; however, older adults with comparable weight changes had relatively greater fat accumulation within IAF and SQAF depots.
KW - Adiposity
KW - Aging
KW - Intra-abdominal fat
KW - Japanese-American
KW - Longitudinal
UR - http://www.scopus.com/inward/record.url?scp=77953811057&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953811057&partnerID=8YFLogxK
U2 - 10.1016/j.diabres.2010.03.006
DO - 10.1016/j.diabres.2010.03.006
M3 - Article
C2 - 20392506
AN - SCOPUS:77953811057
VL - 89
SP - 58
EP - 64
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
IS - 1
ER -