TY - JOUR
T1 - Intestinal Microbiota, HLA-B27, and Spondyloarthritis
T2 - Dangerous Liaisons
AU - Dumas, Emilie
AU - Venken, Koen
AU - Rosenbaum, James T.
AU - Elewaut, Dirk
N1 - Funding Information:
E. Dumas is the holder of an individual Marie Skłodowska Curie Actions grant. K. Venken is supported by Fonds voor Wetenschappelijk Onderzoek Vlaanderen ( FWO-Vl ) and Flanders Innovation & Entrepreneurship ( VLAIO ). D. Elewaut is supported by FWO-Vl, Research Council of Ghent University , and interuniversity Attraction Pole grant Devrepair from Belspo Agency (project P7/07) and an FWO Excellence of Science Grant. J.T. Rosenbaum received support from NIH (grant RO EY029266 ) and the William and Mary Bauman Foundation , the Stan and Madelle Rosenfeld Family Trust , and the Grandmaison Fund for Autoimmunity Research.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/5
Y1 - 2020/5
N2 - Spondyloarthritis, although primarily a joint-centered disease, is associated with extra-articular features, such as gut inflammation, psoriasis, and/or uveitis. Evidence points to underlying genetic predisposing factors and/or environmental factors. This is most clear in the gut, with progress through 16S and metagenomics sequencing studies and the results of functional studies in preclinical arthritis models. Translation of these findings to the clinic is making progress based on encouraging results of fecal microbial transplant studies in several human diseases. This review elaborates on novel trends in host-microbial interplay in spondyloarthritis, focusing on microbiota, immune dysregulation, and disease progression, and modulation by HLA-B27.
AB - Spondyloarthritis, although primarily a joint-centered disease, is associated with extra-articular features, such as gut inflammation, psoriasis, and/or uveitis. Evidence points to underlying genetic predisposing factors and/or environmental factors. This is most clear in the gut, with progress through 16S and metagenomics sequencing studies and the results of functional studies in preclinical arthritis models. Translation of these findings to the clinic is making progress based on encouraging results of fecal microbial transplant studies in several human diseases. This review elaborates on novel trends in host-microbial interplay in spondyloarthritis, focusing on microbiota, immune dysregulation, and disease progression, and modulation by HLA-B27.
KW - HLA-B27
KW - Innate mucosal immunity
KW - Microbiota
KW - Spondyloarthritis
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U2 - 10.1016/j.rdc.2020.01.007
DO - 10.1016/j.rdc.2020.01.007
M3 - Review article
C2 - 32340697
AN - SCOPUS:85083563987
SN - 0889-857X
VL - 46
SP - 213
EP - 224
JO - Rheumatic Disease Clinics of North America
JF - Rheumatic Disease Clinics of North America
IS - 2
ER -