Intersubject variability of brain glucose metabolic measurements in young normal males

G. J. Wang, N. D. Volkow, A. P. Wolf, J. D. Brodie, Robert Hitzemann

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

This study evaluates intersubject variability on regional glucose metabolic values in a group of 50 healthy right-handed males between 20 and 40 yr of age. Methods: Brain glucose metabolism was measured using PET and 2- deoxy-2[18F]fluoro-D-glucose under resting conditions and was separately assessed for subjects in their twenties (n = 34) and those in their thirties (n = 16). Results: Regional brain metabolic values showed significant intersubject variability with coefficients of variation (CV) that ranged between 11.1% to 15.2% (twenties) and 7.2% to 12.6% (thirties). Relative measures (regional/global) were less variable than absolute measures and the CV ranged between 4.1% to 8.3% (twenties) and 3.9% to 10% (thirties). Whereas global brain metabolic rate for subjects in their twenties was not significantly different from that of subjects in their thirties, the metabolic rate in left frontal regions was significantly lower in the older subjects. Conclusion: The correlations between age and absolute and relative metabolism in the left frontal region were r = 0.438, p <0.002 and r = 0.447, p <0.001, respectively. This study shows significant intersubject variability for regional brain metabolic values in normal controls and documents age-related decreases in frontal metabolism that occur even in relatively young adults.

Original languageEnglish (US)
Pages (from-to)1457-1466
Number of pages10
JournalJournal of Nuclear Medicine
Volume35
Issue number9
StatePublished - 1994
Externally publishedYes

Fingerprint

Glucose
Brain
Fluorodeoxyglucose F18
Young Adult
Reference Values

Keywords

  • cerebral glucose metabolism
  • intersubject viability
  • PET

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Intersubject variability of brain glucose metabolic measurements in young normal males. / Wang, G. J.; Volkow, N. D.; Wolf, A. P.; Brodie, J. D.; Hitzemann, Robert.

In: Journal of Nuclear Medicine, Vol. 35, No. 9, 1994, p. 1457-1466.

Research output: Contribution to journalArticle

Wang, G. J. ; Volkow, N. D. ; Wolf, A. P. ; Brodie, J. D. ; Hitzemann, Robert. / Intersubject variability of brain glucose metabolic measurements in young normal males. In: Journal of Nuclear Medicine. 1994 ; Vol. 35, No. 9. pp. 1457-1466.
@article{5a49d97a3ce249b9b669055d27e1c724,
title = "Intersubject variability of brain glucose metabolic measurements in young normal males",
abstract = "This study evaluates intersubject variability on regional glucose metabolic values in a group of 50 healthy right-handed males between 20 and 40 yr of age. Methods: Brain glucose metabolism was measured using PET and 2- deoxy-2[18F]fluoro-D-glucose under resting conditions and was separately assessed for subjects in their twenties (n = 34) and those in their thirties (n = 16). Results: Regional brain metabolic values showed significant intersubject variability with coefficients of variation (CV) that ranged between 11.1{\%} to 15.2{\%} (twenties) and 7.2{\%} to 12.6{\%} (thirties). Relative measures (regional/global) were less variable than absolute measures and the CV ranged between 4.1{\%} to 8.3{\%} (twenties) and 3.9{\%} to 10{\%} (thirties). Whereas global brain metabolic rate for subjects in their twenties was not significantly different from that of subjects in their thirties, the metabolic rate in left frontal regions was significantly lower in the older subjects. Conclusion: The correlations between age and absolute and relative metabolism in the left frontal region were r = 0.438, p <0.002 and r = 0.447, p <0.001, respectively. This study shows significant intersubject variability for regional brain metabolic values in normal controls and documents age-related decreases in frontal metabolism that occur even in relatively young adults.",
keywords = "cerebral glucose metabolism, intersubject viability, PET",
author = "Wang, {G. J.} and Volkow, {N. D.} and Wolf, {A. P.} and Brodie, {J. D.} and Robert Hitzemann",
year = "1994",
language = "English (US)",
volume = "35",
pages = "1457--1466",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "9",

}

TY - JOUR

T1 - Intersubject variability of brain glucose metabolic measurements in young normal males

AU - Wang, G. J.

AU - Volkow, N. D.

AU - Wolf, A. P.

AU - Brodie, J. D.

AU - Hitzemann, Robert

PY - 1994

Y1 - 1994

N2 - This study evaluates intersubject variability on regional glucose metabolic values in a group of 50 healthy right-handed males between 20 and 40 yr of age. Methods: Brain glucose metabolism was measured using PET and 2- deoxy-2[18F]fluoro-D-glucose under resting conditions and was separately assessed for subjects in their twenties (n = 34) and those in their thirties (n = 16). Results: Regional brain metabolic values showed significant intersubject variability with coefficients of variation (CV) that ranged between 11.1% to 15.2% (twenties) and 7.2% to 12.6% (thirties). Relative measures (regional/global) were less variable than absolute measures and the CV ranged between 4.1% to 8.3% (twenties) and 3.9% to 10% (thirties). Whereas global brain metabolic rate for subjects in their twenties was not significantly different from that of subjects in their thirties, the metabolic rate in left frontal regions was significantly lower in the older subjects. Conclusion: The correlations between age and absolute and relative metabolism in the left frontal region were r = 0.438, p <0.002 and r = 0.447, p <0.001, respectively. This study shows significant intersubject variability for regional brain metabolic values in normal controls and documents age-related decreases in frontal metabolism that occur even in relatively young adults.

AB - This study evaluates intersubject variability on regional glucose metabolic values in a group of 50 healthy right-handed males between 20 and 40 yr of age. Methods: Brain glucose metabolism was measured using PET and 2- deoxy-2[18F]fluoro-D-glucose under resting conditions and was separately assessed for subjects in their twenties (n = 34) and those in their thirties (n = 16). Results: Regional brain metabolic values showed significant intersubject variability with coefficients of variation (CV) that ranged between 11.1% to 15.2% (twenties) and 7.2% to 12.6% (thirties). Relative measures (regional/global) were less variable than absolute measures and the CV ranged between 4.1% to 8.3% (twenties) and 3.9% to 10% (thirties). Whereas global brain metabolic rate for subjects in their twenties was not significantly different from that of subjects in their thirties, the metabolic rate in left frontal regions was significantly lower in the older subjects. Conclusion: The correlations between age and absolute and relative metabolism in the left frontal region were r = 0.438, p <0.002 and r = 0.447, p <0.001, respectively. This study shows significant intersubject variability for regional brain metabolic values in normal controls and documents age-related decreases in frontal metabolism that occur even in relatively young adults.

KW - cerebral glucose metabolism

KW - intersubject viability

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=0028067751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028067751&partnerID=8YFLogxK

M3 - Article

C2 - 8071692

AN - SCOPUS:0028067751

VL - 35

SP - 1457

EP - 1466

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 9

ER -