Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance

Sunwen Chou, Nell S. Lurain, Adriana Weinberg, Guang Yung Cai, Prem L. Sharma, Clyde S. Crumpacker

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.

Original languageEnglish (US)
Pages (from-to)1500-1502
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume43
Issue number6
StatePublished - Jun 1 1999

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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