The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.
|Original language||English (US)|
|Number of pages||3|
|Journal||Antimicrobial agents and chemotherapy|
|State||Published - Jun 1 1999|
ASJC Scopus subject areas
- Pharmacology (medical)
- Infectious Diseases