Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance

Sunwen Chou; Nell S. Lurain; Adriana Weinberg; Guang Yung Cai; Prem L. Sharma; Clyde S. Crumpacker

doi:10.1128/aac.43.6.1500

Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance

Sunwen Chou, Nell S. Lurain, Adriana Weinberg, Guang Yung Cai, Prem L. Sharma, Clyde S. Crumpacker

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.

Original language	English (US)
Pages (from-to)	1500-1502
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	43
Issue number	6
DOIs	https://doi.org/10.1128/aac.43.6.1500
State	Published - Jun 1999
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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AU - Chou, Sunwen

AU - Lurain, Nell S.

AU - Weinberg, Adriana

AU - Cai, Guang Yung

AU - Sharma, Prem L.

AU - Crumpacker, Clyde S.

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AB - The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.

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Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance

Abstract

ASJC Scopus subject areas

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