Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance

Sunwen Chou, Nell S. Lurain, Adriana Weinberg, Guang Yung Cai, Prem L. Sharma, Clyde S. Crumpacker

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1,237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.

Original languageEnglish (US)
Pages (from-to)1500-1502
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number6
StatePublished - Jun 1999
Externally publishedYes

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Viral Drug Resistance
Foscarnet
Ganciclovir
Sequence Alignment
DNA-Directed DNA Polymerase
Cytomegalovirus
Codon
Amino Acids
Mutation

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. / Chou, Sunwen; Lurain, Nell S.; Weinberg, Adriana; Cai, Guang Yung; Sharma, Prem L.; Crumpacker, Clyde S.

In: Antimicrobial Agents and Chemotherapy, Vol. 43, No. 6, 06.1999, p. 1500-1502.

Research output: Contribution to journalArticle

Chou, Sunwen ; Lurain, Nell S. ; Weinberg, Adriana ; Cai, Guang Yung ; Sharma, Prem L. ; Crumpacker, Clyde S. / Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. In: Antimicrobial Agents and Chemotherapy. 1999 ; Vol. 43, No. 6. pp. 1500-1502.
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