Interrelationships among atrial peptides, renin, and blood volume in pregnant rats

A. S. Nadel, B. J. Ballermann, S. Anderson, B. M. Brenner, S. J. Downes, J. L. Troy

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

To determine how changes in intravascular volume are sensed by atrial and renal volume receptors during pregnancy and the puerperium, circulating atrial natriuretic peptide (ANP) levels and plasma renin activity (PRA) were measured in conscious chronically catheterized rats on days 9-10, 15-16, 19-20, and 22 of pregnancy, on the first postpartum day, and in nonpregnant controls. Blood volume measured in a separate group of anesthetized rats increased progressively during pregnancy, and circulating ANP levels tended to decline, although not significantly below the nonpregnant value of 132 ± 9 pg/ml (mean ± SE). PRA remained similar to the non-pregnant value of 5.5 ± 0.6 ng angiotensin I·ml-1·h-1 until day 22 of pregnancy, when it rose to 14.1 ± 1.8 ng angiotensin I·ml-1·h-1 (P < 0.001 vs. nonpregnant). In pregnant rats, PRA was suppressed after uninephrectomy and chronic administration of deoxycorticosterone and saline, demonstrating the ability of this hormonal system to respond appropriately to further increments in volume induced during pregnancy. On the first postpartum day plasma ANP rose to 268 ± 26 pg/ml, and PRA fell to 3.6 ± 0.4 ng angiotensin I·ml-1·h-1 (P < 0.005 and P < 0.05 vs. nonpregnant values, respectively). Thus it appears that the increased blood volume in normal pregnancy is not sensed by renal or atrial volume sensors, presumably because it is accommodated by an enlarged maternal vascular compartment. In the puerperium, however, due to the decreased size of the maternal vascular compartment, atrial and renal volume sensors recognize the intravascular volume as expanded. The resultant stimulation of ANP release and suppression of renin may play a role in the subsequent maternal diuresis and natriuresis, thereby returning maternal blood volume toward non-pregnant levels.

Original languageEnglish (US)
Pages (from-to)23/5
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume254
Issue number5
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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