Abstract
Cognitive neuroscience depends on the use of blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to probe brain function.Although commonly used as a surrogatemeasure of neuronal activity, BOLD signals actually reflect changes in brain blood oxygenation.Understanding the mechanisms linking neuronal activity to vascular perfusion is, therefore, critical in interpreting BOLD.Advances in cellular neuroscience demonstrating differences in this neurovascular relationship in different brain regions, conditions or pathologies are often not accounted for when interpreting BOLD.Meanwhile, within cognitive neuroscience, the increasing use of high magnetic field strengths and the development of model-based tasks and analyses have broadened the capability of BOLD signals to inform us about the underlying neuronal activity, but these methods are lesswell understood by cellular neuroscientists.In 2016, a Royal Society TheoMurphyMeeting brought scientists from the two communities together to discuss these issues.Here, we consolidate the main conclusions arising from that meeting.We discuss areas of consensus about what BOLD fMRI can tell us about underlying neuronal activity, and how advanced modelling techniques have improved our ability to use and interpret BOLD.We also highlight areas of controversy in understanding BOLD and suggest research directions required to resolve these issues.
| Original language | English (US) |
|---|---|
| Article number | 20150348 |
| Journal | Philosophical Transactions of the Royal Society B: Biological Sciences |
| Volume | 371 |
| Issue number | 1705 |
| DOIs | |
| State | Published - Oct 5 2016 |
| Externally published | Yes |
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Keywords
- BOLD
- Cellular neuroscience
- Cognitive neuroscience
- Disease
- fMRI
- Neurovascular
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
Cite this
Interpreting bold : Towards a dialogue between cognitive and cellular neuroscience. / Hall, Catherine N.; Howarth, Clare; Kurth-Nelson, Zebulun; Mishra, Anusha.
In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 371, No. 1705, 20150348, 05.10.2016.Research output: Contribution to journal › Editorial
}
TY - JOUR
T1 - Interpreting bold
T2 - Towards a dialogue between cognitive and cellular neuroscience
AU - Hall, Catherine N.
AU - Howarth, Clare
AU - Kurth-Nelson, Zebulun
AU - Mishra, Anusha
PY - 2016/10/5
Y1 - 2016/10/5
N2 - Cognitive neuroscience depends on the use of blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to probe brain function.Although commonly used as a surrogatemeasure of neuronal activity, BOLD signals actually reflect changes in brain blood oxygenation.Understanding the mechanisms linking neuronal activity to vascular perfusion is, therefore, critical in interpreting BOLD.Advances in cellular neuroscience demonstrating differences in this neurovascular relationship in different brain regions, conditions or pathologies are often not accounted for when interpreting BOLD.Meanwhile, within cognitive neuroscience, the increasing use of high magnetic field strengths and the development of model-based tasks and analyses have broadened the capability of BOLD signals to inform us about the underlying neuronal activity, but these methods are lesswell understood by cellular neuroscientists.In 2016, a Royal Society TheoMurphyMeeting brought scientists from the two communities together to discuss these issues.Here, we consolidate the main conclusions arising from that meeting.We discuss areas of consensus about what BOLD fMRI can tell us about underlying neuronal activity, and how advanced modelling techniques have improved our ability to use and interpret BOLD.We also highlight areas of controversy in understanding BOLD and suggest research directions required to resolve these issues.
AB - Cognitive neuroscience depends on the use of blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to probe brain function.Although commonly used as a surrogatemeasure of neuronal activity, BOLD signals actually reflect changes in brain blood oxygenation.Understanding the mechanisms linking neuronal activity to vascular perfusion is, therefore, critical in interpreting BOLD.Advances in cellular neuroscience demonstrating differences in this neurovascular relationship in different brain regions, conditions or pathologies are often not accounted for when interpreting BOLD.Meanwhile, within cognitive neuroscience, the increasing use of high magnetic field strengths and the development of model-based tasks and analyses have broadened the capability of BOLD signals to inform us about the underlying neuronal activity, but these methods are lesswell understood by cellular neuroscientists.In 2016, a Royal Society TheoMurphyMeeting brought scientists from the two communities together to discuss these issues.Here, we consolidate the main conclusions arising from that meeting.We discuss areas of consensus about what BOLD fMRI can tell us about underlying neuronal activity, and how advanced modelling techniques have improved our ability to use and interpret BOLD.We also highlight areas of controversy in understanding BOLD and suggest research directions required to resolve these issues.
KW - BOLD
KW - Cellular neuroscience
KW - Cognitive neuroscience
KW - Disease
KW - fMRI
KW - Neurovascular
UR - http://www.scopus.com/inward/record.url?scp=84984918843&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84984918843&partnerID=8YFLogxK
U2 - 10.1098/rstb.2015.0348
DO - 10.1098/rstb.2015.0348
M3 - Editorial
C2 - 27574302
AN - SCOPUS:84984918843
VL - 371
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
SN - 0962-8436
IS - 1705
M1 - 20150348
ER -