International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors

Jörg Hamann, Gabriela Aust, Demet Araç, Felix B. Engel, Caroline Formstone, Robert Fredriksson, Randy A. Hall, Breanne L. Harty, Christiane Kirchhoff, Barbara Knapp, Arunkumar Krishnan, Ines Liebscher, Hsi Hsien Lin, David C. Martinelli, Kelly Monk, Miriam C. Peeters, Xianhua Piao, Simone Prömel, Torsten Schöneberg, Thue W. SchwartzKathleen Singer, Martin Stacey, Yuri A. Ushkaryov, Mario Vallon, Uwe Wolfrum, Mathew W. Wright, Lei Xu, Tobias Langenhan, Helgi B. Schiöth

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

The Adhesion family forms a large branch of the pharmacologically important super-family of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

Original languageEnglish (US)
Pages (from-to)338-367
Number of pages30
JournalPharmacological Reviews
Volume67
Issue number2
DOIs
StatePublished - Feb 23 2015
Externally publishedYes

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Clinical Pharmacology
G-Protein-Coupled Receptors
Names
Terminology
Drug Receptors
alpha-latrotoxin receptor

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Hamann, J., Aust, G., Araç, D., Engel, F. B., Formstone, C., Fredriksson, R., ... Schiöth, H. B. (2015). International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors. Pharmacological Reviews, 67(2), 338-367. https://doi.org/10.1124/pr.114.009647

International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors. / Hamann, Jörg; Aust, Gabriela; Araç, Demet; Engel, Felix B.; Formstone, Caroline; Fredriksson, Robert; Hall, Randy A.; Harty, Breanne L.; Kirchhoff, Christiane; Knapp, Barbara; Krishnan, Arunkumar; Liebscher, Ines; Lin, Hsi Hsien; Martinelli, David C.; Monk, Kelly; Peeters, Miriam C.; Piao, Xianhua; Prömel, Simone; Schöneberg, Torsten; Schwartz, Thue W.; Singer, Kathleen; Stacey, Martin; Ushkaryov, Yuri A.; Vallon, Mario; Wolfrum, Uwe; Wright, Mathew W.; Xu, Lei; Langenhan, Tobias; Schiöth, Helgi B.

In: Pharmacological Reviews, Vol. 67, No. 2, 23.02.2015, p. 338-367.

Research output: Contribution to journalArticle

Hamann, J, Aust, G, Araç, D, Engel, FB, Formstone, C, Fredriksson, R, Hall, RA, Harty, BL, Kirchhoff, C, Knapp, B, Krishnan, A, Liebscher, I, Lin, HH, Martinelli, DC, Monk, K, Peeters, MC, Piao, X, Prömel, S, Schöneberg, T, Schwartz, TW, Singer, K, Stacey, M, Ushkaryov, YA, Vallon, M, Wolfrum, U, Wright, MW, Xu, L, Langenhan, T & Schiöth, HB 2015, 'International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors', Pharmacological Reviews, vol. 67, no. 2, pp. 338-367. https://doi.org/10.1124/pr.114.009647
Hamann, Jörg ; Aust, Gabriela ; Araç, Demet ; Engel, Felix B. ; Formstone, Caroline ; Fredriksson, Robert ; Hall, Randy A. ; Harty, Breanne L. ; Kirchhoff, Christiane ; Knapp, Barbara ; Krishnan, Arunkumar ; Liebscher, Ines ; Lin, Hsi Hsien ; Martinelli, David C. ; Monk, Kelly ; Peeters, Miriam C. ; Piao, Xianhua ; Prömel, Simone ; Schöneberg, Torsten ; Schwartz, Thue W. ; Singer, Kathleen ; Stacey, Martin ; Ushkaryov, Yuri A. ; Vallon, Mario ; Wolfrum, Uwe ; Wright, Mathew W. ; Xu, Lei ; Langenhan, Tobias ; Schiöth, Helgi B. / International union of basic and clinical pharmacology. XCIV. adhesion G protein-coupled receptors. In: Pharmacological Reviews. 2015 ; Vol. 67, No. 2. pp. 338-367.
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AU - Formstone, Caroline

AU - Fredriksson, Robert

AU - Hall, Randy A.

AU - Harty, Breanne L.

AU - Kirchhoff, Christiane

AU - Knapp, Barbara

AU - Krishnan, Arunkumar

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AU - Singer, Kathleen

AU - Stacey, Martin

AU - Ushkaryov, Yuri A.

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AU - Wolfrum, Uwe

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N2 - The Adhesion family forms a large branch of the pharmacologically important super-family of G protein-coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter and a number to denote each subfamily and subtype, respectively. The new names, with old and alternative names within parentheses, are: ADGRA1 (GPR123), ADGRA2 (GPR124), ADGRA3 (GPR125), ADGRB1 (BAI1), ADGRB2 (BAI2), ADGRB3 (BAI3), ADGRC1 (CELSR1), ADGRC2 (CELSR2), ADGRC3 (CELSR3), ADGRD1 (GPR133), ADGRD2 (GPR144), ADGRE1 (EMR1, F4/80), ADGRE2 (EMR2), ADGRE3 (EMR3), ADGRE4 (EMR4), ADGRE5 (CD97), ADGRF1 (GPR110), ADGRF2 (GPR111), ADGRF3 (GPR113), ADGRF4 (GPR115), ADGRF5 (GPR116, Ig-Hepta), ADGRG1 (GPR56), ADGRG2 (GPR64, HE6), ADGRG3 (GPR97), ADGRG4 (GPR112), ADGRG5 (GPR114), ADGRG6 (GPR126), ADGRG7 (GPR128), ADGRL1 (latrophilin-1, CIRL-1, CL1), ADGRL2 (latrophilin-2, CIRL-2, CL2), ADGRL3 (latrophilin-3, CIRL-3, CL3), ADGRL4 (ELTD1, ETL), and ADGRV1 (VLGR1, GPR98). This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.

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