Interleukin‐7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

Brian M.J. Foxwell, Carol Beadling, Dimitri Guschin, Ian Kerr, Doreen Cantrell

    Research output: Contribution to journalArticle

    97 Scopus citations

    Abstract

    The activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins has recently been linked to the signal transduction mechanism of several cytokines. IL‐7 was observed to induce a rapid and dose‐dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple STAT proteins. The STAT proteins utilized by IL‐7 were identical to those induced by IL‐2 and could be identified as various STAT 5 isoforms. Moreover, the induction of both Jak 1 and 3, and STAT 5 activity strongly correlated with the growth‐promoting effects of IL‐7, suggesting that this signal transduction mechanism may play a key role in IL‐7‐induced proliferation.

    Original languageEnglish (US)
    Pages (from-to)3041-3046
    Number of pages6
    JournalEuropean Journal of Immunology
    Volume25
    Issue number11
    DOIs
    StatePublished - Nov 1995

      Fingerprint

    Keywords

    • Interleukin‐2
    • Interleukin‐7
    • Jak
    • STAT
    • Signal transduction
    • Tyrosine kinase

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology

    Cite this