Interleukin‐7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

Brian M.J. Foxwell, Carol Beadling, Dimitri Guschin, Ian Kerr, Doreen Cantrell

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

The activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins has recently been linked to the signal transduction mechanism of several cytokines. IL‐7 was observed to induce a rapid and dose‐dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple STAT proteins. The STAT proteins utilized by IL‐7 were identical to those induced by IL‐2 and could be identified as various STAT 5 isoforms. Moreover, the induction of both Jak 1 and 3, and STAT 5 activity strongly correlated with the growth‐promoting effects of IL‐7, suggesting that this signal transduction mechanism may play a key role in IL‐7‐induced proliferation.

Original languageEnglish (US)
Pages (from-to)3041-3046
Number of pages6
JournalEuropean Journal of Immunology
Volume25
Issue number11
DOIs
StatePublished - Nov 1995
Externally publishedYes

Keywords

  • Interleukin‐2
  • Interleukin‐7
  • Jak
  • STAT
  • Signal transduction
  • Tyrosine kinase

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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