Interleukin-10 inhibits inflammation after extracapsular lens extraction and intraocular lens implantation

M. J. Balish, J. M. Park, J. T. Rosenbaum

Research output: Contribution to journalArticle

Abstract

Purpose: Over 1.3 million cataract operations are performed in the United States annually. Post operative inflammation is common early, and can lead to cystoid macular edema and limited visual outcome. We have shown IL-10 inhibits the intra-ocular inflammation caused by endotoxin. We have now begun to study IL-10's effects on inflammation caused by lens extraction and intraocular lens implantation. Methods: Six rabbits underwent extracapsular lens extraction and intraocular lens implantation in the left eye. Half received an intravitreal injection of human recombinant IL-10 (Schering-Plough), 1 μg, and half received diluent control in the operative eye 2-4 hours prior to surgery. Inflammation was scored clinically by slit lamp examination for one week. Also, objective cell counts were made on days 4 and 7 by sacrificing rabbits and performing anterior chamber paracentesis. Results: Control eyes developed 2+ to 3+ cell in the anterior chamber, peaking on post-operative day 3 and subsiding thereafter. IL-10 treated eyes developed trace to 1+ cell in the anterior chamber by day 3 and then subsided. On post-operative day 4, a control eye had 1.6 x 107 cells in the anterior chamber while an IL-10 treated eye had 1.6 x 106 cells. On post-operative day 7 control eyes had 4.5 x 106 and 2.6 x 107 cells in the anterior chamber, versus 5.1 x 106 and 6.1 x 106 cells for IL-10 treated eyes. Conclusions: These preliminary results suggest that IL-10 may cause a 10-fold reduction in post-operative inflammation after extracapsular lens extraction and intraocular lens implantation on day 4.

Original languageEnglish (US)
Pages (from-to)S766
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
StatePublished - Feb 15 1996

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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