Interleukin-1, stromal cells, granulopoiesis, and the inflammatory response

    Research output: Contribution to journalArticle

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    Abstract

    A number of in vitro studies carried out in our laboratory over the past ten years have led to some clarification of the role of mononuclear phagocytes in hematopoietic regulation. The results of these studies have demonstrated that mononuclear phagocytes produce proteins, notably interleukin-1 (IL-1), that induce the expression of multilineage hematopoietic growth factors by human vascular endothelial cells, fibroblasts, T-lymphocytes, and thymic epithelial cells. More recently we and others have identified these induced factors as G-CSF, GM-CSF, IL-6, and IL-1. Although IL-1 seems to stimulate expression of these genes by inducing the accumulation of gene transcripts, interestingly the accumulation results from prolongation of mRNA half-life. We propose that the inductive capacity of IL-1 results from its activation of ribonuclease inhibitory activity in the cytoplasm of IL-1 induced cells and hypothesize that this may be a general mechanism by which IL-1 induces gene expression.

    Original languageEnglish (US)
    Pages (from-to)255-261
    Number of pages7
    JournalBiotherapy
    Volume1
    Issue number4
    DOIs
    StatePublished - Dec 1989

    Fingerprint

    Stromal Cells
    Interleukin-1
    Granulocyte-Macrophage Colony-Stimulating Factor
    Phagocytes
    Gene Expression
    Granulocyte Colony-Stimulating Factor
    Ribonucleases
    Half-Life
    Interleukin-6
    Intercellular Signaling Peptides and Proteins
    Cytoplasm
    Endothelial Cells
    Fibroblasts
    Epithelial Cells
    T-Lymphocytes
    Messenger RNA
    Genes
    Proteins

    ASJC Scopus subject areas

    • Pharmacology

    Cite this

    Interleukin-1, stromal cells, granulopoiesis, and the inflammatory response. / Bagby, Grover C.

    In: Biotherapy, Vol. 1, No. 4, 12.1989, p. 255-261.

    Research output: Contribution to journalArticle

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