Interleukin-1β decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats

Pedro Rada, Gregory P. Mark, Michael P. Vitek, Richard M. Mangano, Arthur J. Blume, Bernard Beer, Bartley G. Hoebel

Research output: Contribution to journalArticle

117 Scopus citations

Abstract

Interleukin (IL-1) is a cytokine which plays an important role in the modulation of the acute in host defense. This cytokine is also increased in patients with Alzheimer's disease. In the present experiment systemic injection of IL-1β (7.5-50 μg/kg) decreased extracellular acetylccholine in the hippocampus. This effect could not be attributed entirely to general malaise since lithium chloride (130 mg/kg) had the opposite effect. Heat-inactivation of the cytokine eliminated the reduction of extracellular ACh. The results give further evidence of a relationship between the immune system and the central nervous system and suggest a possible relationship between IL-1 and cholinergic function or dysfunction in the hippocampus.

Original languageEnglish (US)
Pages (from-to)287-290
Number of pages4
JournalBrain research
Volume550
Issue number2
DOIs
StatePublished - Jun 7 1991

Keywords

  • Acetylcholine
  • Alzheimer's disease
  • Hippocampus
  • Interleukin-1β
  • Microdialysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Rada, P., Mark, G. P., Vitek, M. P., Mangano, R. M., Blume, A. J., Beer, B., & Hoebel, B. G. (1991). Interleukin-1β decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats. Brain research, 550(2), 287-290. https://doi.org/10.1016/0006-8993(91)91330-4