Interleukin-1β decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats

Pedro Rada; Gregory P. Mark; Michael P. Vitek; Richard M. Mangano; Arthur J. Blume; Bernard Beer; Bartley G. Hoebel

doi:10.1016/0006-8993(91)91330-4

Interleukin-1β decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats

Pedro Rada, Gregory P. Mark, Michael P. Vitek, Richard M. Mangano, Arthur J. Blume, Bernard Beer, Bartley G. Hoebel

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

Interleukin (IL-1) is a cytokine which plays an important role in the modulation of the acute in host defense. This cytokine is also increased in patients with Alzheimer's disease. In the present experiment systemic injection of IL-1β (7.5-50 μg/kg) decreased extracellular acetylccholine in the hippocampus. This effect could not be attributed entirely to general malaise since lithium chloride (130 mg/kg) had the opposite effect. Heat-inactivation of the cytokine eliminated the reduction of extracellular ACh. The results give further evidence of a relationship between the immune system and the central nervous system and suggest a possible relationship between IL-1 and cholinergic function or dysfunction in the hippocampus.

Original language	English (US)
Pages (from-to)	287-290
Number of pages	4
Journal	Brain research
Volume	550
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(91)91330-4
State	Published - Jun 7 1991

Keywords

Acetylcholine
Alzheimer's disease
Hippocampus
Interleukin-1β
Microdialysis

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(91)91330-4

Cite this

@article{030c4e6cedd348cba540210bfff4c3b6,

title = "Interleukin-1β decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats",

abstract = "Interleukin (IL-1) is a cytokine which plays an important role in the modulation of the acute in host defense. This cytokine is also increased in patients with Alzheimer's disease. In the present experiment systemic injection of IL-1β (7.5-50 μg/kg) decreased extracellular acetylccholine in the hippocampus. This effect could not be attributed entirely to general malaise since lithium chloride (130 mg/kg) had the opposite effect. Heat-inactivation of the cytokine eliminated the reduction of extracellular ACh. The results give further evidence of a relationship between the immune system and the central nervous system and suggest a possible relationship between IL-1 and cholinergic function or dysfunction in the hippocampus.",

keywords = "Acetylcholine, Alzheimer's disease, Hippocampus, Interleukin-1β, Microdialysis",

author = "Pedro Rada and Mark, {Gregory P.} and Vitek, {Michael P.} and Mangano, {Richard M.} and Blume, {Arthur J.} and Bernard Beer and Hoebel, {Bartley G.}",

note = "Funding Information: Acknowledgements We wish to thank Robert A Ashton for his contnbuUons to this effort and to especially thank Joseph Zaccor& and Vw~an Doelhng for their purification of human Interleukm-lB This research was supported m part by a grant from American Cyanamid Co Inc to BH, RM and MPV and by EG&G Princeton Apphed Res Corp",

year = "1991",

month = jun,

day = "7",

doi = "10.1016/0006-8993(91)91330-4",

language = "English (US)",

volume = "550",

pages = "287--290",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Interleukin-1β decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats

AU - Rada, Pedro

AU - Mark, Gregory P.

AU - Vitek, Michael P.

AU - Mangano, Richard M.

AU - Blume, Arthur J.

AU - Beer, Bernard

AU - Hoebel, Bartley G.

N1 - Funding Information: Acknowledgements We wish to thank Robert A Ashton for his contnbuUons to this effort and to especially thank Joseph Zaccor& and Vw~an Doelhng for their purification of human Interleukm-lB This research was supported m part by a grant from American Cyanamid Co Inc to BH, RM and MPV and by EG&G Princeton Apphed Res Corp

PY - 1991/6/7

Y1 - 1991/6/7

N2 - Interleukin (IL-1) is a cytokine which plays an important role in the modulation of the acute in host defense. This cytokine is also increased in patients with Alzheimer's disease. In the present experiment systemic injection of IL-1β (7.5-50 μg/kg) decreased extracellular acetylccholine in the hippocampus. This effect could not be attributed entirely to general malaise since lithium chloride (130 mg/kg) had the opposite effect. Heat-inactivation of the cytokine eliminated the reduction of extracellular ACh. The results give further evidence of a relationship between the immune system and the central nervous system and suggest a possible relationship between IL-1 and cholinergic function or dysfunction in the hippocampus.

AB - Interleukin (IL-1) is a cytokine which plays an important role in the modulation of the acute in host defense. This cytokine is also increased in patients with Alzheimer's disease. In the present experiment systemic injection of IL-1β (7.5-50 μg/kg) decreased extracellular acetylccholine in the hippocampus. This effect could not be attributed entirely to general malaise since lithium chloride (130 mg/kg) had the opposite effect. Heat-inactivation of the cytokine eliminated the reduction of extracellular ACh. The results give further evidence of a relationship between the immune system and the central nervous system and suggest a possible relationship between IL-1 and cholinergic function or dysfunction in the hippocampus.

KW - Acetylcholine

KW - Alzheimer's disease

KW - Hippocampus

KW - Interleukin-1β

KW - Microdialysis

UR - http://www.scopus.com/inward/record.url?scp=0025818355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025818355&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(91)91330-4

DO - 10.1016/0006-8993(91)91330-4

M3 - Article

C2 - 1884236

AN - SCOPUS:0025818355

SN - 0006-8993

VL - 550

SP - 287

EP - 290

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Interleukin-1β decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this