Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection

Ulrike Protzer, Michael Nassal, Pei Wen Chiang, Michael Kirschfink, Heinz Schaller

Research output: Contribution to journalArticle

88 Scopus citations

Abstract

Hepatitis B viruses specifically target the liver, where they efficiently infect quiescent hepatocytes. Here we show that human and avian hepatitis B viruses can be converted into vectors for liver-directed gene transfer. These vectors allow hepatocyte-specific expression of a green fluorescent protein in vitro and in vivo. Moreover, when used to transduce a type I interferon gene, expression of interferon efficiently suppresses wild- type virus replication in the duck model of hepatitis B virus infection. These data suggest local cytokine production after hepatitis-B-virus-mediated gene transfer as a promising concept for the treatment of acquired liver diseases, including chronic hepatitis B.

Original languageEnglish (US)
Pages (from-to)10818-10823
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number19
DOIs
StatePublished - Sep 14 1999

ASJC Scopus subject areas

  • General

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