Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

Jo Ann L. Yee, Kamm Prongay, Brodie Miles, Jeremy Smedley, Scott Hansen, Michael Axthelm, Amir Ardeshir, Koen K.A. Van Rompay, Gregory Timmel, Jeffrey A. Roberts

Research output: Contribution to journal › Article

Abstract

We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.

Original languageEnglish (US)
JournalJournal of medical primatology
DOIs
StatePublished - Jan 1 2019

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Mycobacterium tuberculosis complex
Macaca mulatta
interferon-gamma
Mycobacterium tuberculosis
Primates
Interferon-gamma
immune response
blood
assays
Infection
infection
animals
testing
sampling

Keywords

  • cell-mediated immune response (CMI)
  • interferon-gamma release assay (IGRA)
  • purified protein derivative—tuberculin (PPD)

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates. / Yee, Jo Ann L.; Prongay, Kamm; Miles, Brodie; Smedley, Jeremy; Hansen, Scott; Axthelm, Michael; Ardeshir, Amir; Van Rompay, Koen K.A.; Timmel, Gregory; Roberts, Jeffrey A.

In: Journal of medical primatology, 01.01.2019.

Research output: Contribution to journal › Article

Yee, JAL, Prongay, K, Miles, B, Smedley, J, Hansen, S, Axthelm, M, Ardeshir, A, Van Rompay, KKA, Timmel, G & Roberts, JA 2019, 'Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates', Journal of medical primatology. https://doi.org/10.1111/jmp.12420
Yee JAL, Prongay K, Miles B, Smedley J, Hansen S, Axthelm M et al. Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates. Journal of medical primatology. 2019 Jan 1. https://doi.org/10.1111/jmp.12420
Yee, Jo Ann L. ; Prongay, Kamm ; Miles, Brodie ; Smedley, Jeremy ; Hansen, Scott ; Axthelm, Michael ; Ardeshir, Amir ; Van Rompay, Koen K.A. ; Timmel, Gregory ; Roberts, Jeffrey A. / Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates. In: Journal of medical primatology. 2019.
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