Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

Jo Ann L. Yee; Kamm Prongay; Brodie Miles; Jeremy Smedley; Scott G. Hansen; Michael K. Axthelm; Amir Ardeshir; Koen K.A. Van Rompay; Gregory Timmel; Jeffrey A. Roberts

doi:10.1111/jmp.12420

Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

Jo Ann L. Yee, Kamm Prongay, Brodie Miles, Jeremy Smedley, Scott G. Hansen, Michael K. Axthelm, Amir Ardeshir, Koen K.A. Van Rompay, Gregory Timmel, Jeffrey A. Roberts

Research output: Contribution to journal › Article

Abstract

We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.

Original language	English (US)
Pages (from-to)	260-263
Number of pages	4
Journal	Journal of medical primatology
Volume	48
Issue number	4
DOIs	https://doi.org/10.1111/jmp.12420
State	Published - Aug 2019

Keywords

cell-mediated immune response (CMI)
interferon-gamma release assay (IGRA)
purified protein derivative—tuberculin (PPD)

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

Access to Document

10.1111/jmp.12420

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Yee, J. A. L., Prongay, K., Miles, B., Smedley, J., Hansen, S. G., Axthelm, M. K., Ardeshir, A., Van Rompay, K. K. A., Timmel, G., & Roberts, J. A. (2019). Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates. Journal of medical primatology, 48(4), 260-263. https://doi.org/10.1111/jmp.12420

Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates. / Yee, Jo Ann L.; Prongay, Kamm; Miles, Brodie; Smedley, Jeremy ; Hansen, Scott G.; Axthelm, Michael K.; Ardeshir, Amir; Van Rompay, Koen K.A.; Timmel, Gregory; Roberts, Jeffrey A.

In: Journal of medical primatology, Vol. 48, No. 4, 08.2019, p. 260-263.

Research output: Contribution to journal › Article

Yee, Jo Ann L. ; Prongay, Kamm ; Miles, Brodie ; Smedley, Jeremy ; Hansen, Scott G. ; Axthelm, Michael K. ; Ardeshir, Amir ; Van Rompay, Koen K.A. ; Timmel, Gregory ; Roberts, Jeffrey A. / Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates. In: Journal of medical primatology. 2019 ; Vol. 48, No. 4. pp. 260-263.

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