Interferon-Gamma test for the detection of Mycobacterium tuberculosis complex infection in Macaca mulatta and other non-human primates

Jo Ann L. Yee, Kamm Prongay, Brodie Miles, Jeremy Smedley, Scott G. Hansen, Michael K. Axthelm, Amir Ardeshir, Koen K.A. Van Rompay, Gregory Timmel, Jeffrey A. Roberts

Research output: Contribution to journalArticle

Abstract

We have formatted an assay to detect Mycobacterium tuberculosis complex infections of non-human primates. Commercially available reagents were used to elicit a specific immune response that was measured by interferon-gamma release. Initial evaluation using blood samples from Rhesus macaques experimentally infected with M tuberculosis distinguished infected versus uninfected animals.

Original languageEnglish (US)
Pages (from-to)260-263
Number of pages4
JournalJournal of medical primatology
Volume48
Issue number4
DOIs
StatePublished - Aug 2019

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Keywords

  • cell-mediated immune response (CMI)
  • interferon-gamma release assay (IGRA)
  • purified protein derivative—tuberculin (PPD)

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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