Abstract
Purpose: To determine the efficacy of interferon alpha 2b in the treatment of refractory, uveitic cystoid macular edema (CME). Methods: Retrospective chart review of 4 patients attending the uveitis clinic at the Casey Eye Institute, Oregon Health & Science University. Results: All 4 patients had uveitis and refractory CME, resistant to a variety of immunosuppressants. All patients, except one with severe scleral thinning, had tried and failed therapy with locally injected corticosteroids. Treatment with systemic interferon alpha 2b produced dramatic improvement in CME (central macular thickness: 563 to 267m, p=.002) and visual acuity (logMAR: +0.81 to +0.45, p=.0004) in all 4 cases. All patients have been able to reduce the interferon dosage, but none has discontinued it completely. All patients had some mild adverse response that did not necessitate stopping therapy. Conclusions: Interferon alpha 2b is an effective option to treat refractory CME secondary to uveitis.
Original language | English (US) |
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Pages (from-to) | 86-90 |
Number of pages | 5 |
Journal | Ocular Immunology and Inflammation |
Volume | 20 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2012 |
Keywords
- Cystoid
- Edema
- Interferon alpha 2b
- Macular
- Uveitis
ASJC Scopus subject areas
- Immunology and Allergy
- Ophthalmology