Interference with S and G2 phase progression by polyamine synthesis inhibitors

O. Heby, G. Andersson, J. W. Gray

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

The distribution of Ehrlich ascites tumor cells in the cell cycle was studied by flow cytometry following treatment with α-methyl ornithine (αMO) or methylglyoxal-bis(guanylhydrazone) (MeGAG). αMO and MeGAG are potent inhibitors of ornithine decarboxylase (putrescine synthesis) and S-adenosyl-methionine decarboxylase (spermidine and spermine synthesis), respectively. The data show that these polyamine synthesis inhibitors produce significant cell cycle perturbations resulting in an accumulation of cells in S and G2. This fact suggests that a normal polyamine complement is essential for the progression through these phases of the cell cycle.

Original languageEnglish (US)
Pages (from-to)461-464
Number of pages4
JournalExperimental Cell Research
Volume111
Issue number2
DOIs
StatePublished - Feb 1978

ASJC Scopus subject areas

  • Cell Biology

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