Abstract
The distribution of Ehrlich ascites tumor cells in the cell cycle was studied by flow cytometry following treatment with α-methyl ornithine (αMO) or methylglyoxal-bis(guanylhydrazone) (MeGAG). αMO and MeGAG are potent inhibitors of ornithine decarboxylase (putrescine synthesis) and S-adenosyl-methionine decarboxylase (spermidine and spermine synthesis), respectively. The data show that these polyamine synthesis inhibitors produce significant cell cycle perturbations resulting in an accumulation of cells in S and G2. This fact suggests that a normal polyamine complement is essential for the progression through these phases of the cell cycle.
Original language | English (US) |
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Pages (from-to) | 461-464 |
Number of pages | 4 |
Journal | Experimental Cell Research |
Volume | 111 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1978 |
Externally published | Yes |
ASJC Scopus subject areas
- Cell Biology