Interference with S and G2 phase progression by polyamine synthesis inhibitors

O. Heby, G. Andersson, Joe Gray

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The distribution of Ehrlich ascites tumor cells in the cell cycle was studied by flow cytometry following treatment with α-methyl ornithine (αMO) or methylglyoxal-bis(guanylhydrazone) (MeGAG). αMO and MeGAG are potent inhibitors of ornithine decarboxylase (putrescine synthesis) and S-adenosyl-methionine decarboxylase (spermidine and spermine synthesis), respectively. The data show that these polyamine synthesis inhibitors produce significant cell cycle perturbations resulting in an accumulation of cells in S and G2. This fact suggests that a normal polyamine complement is essential for the progression through these phases of the cell cycle.

Original languageEnglish (US)
Pages (from-to)461-464
Number of pages4
JournalExperimental Cell Research
Volume111
Issue number2
DOIs
StatePublished - 1978
Externally publishedYes

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G2 Phase
Polyamines
Mitoguazone
S Phase
Cell Cycle
Ornithine
Ehrlich Tumor Carcinoma
Putrescine
Spermidine
Spermine
Flow Cytometry

ASJC Scopus subject areas

  • Cell Biology

Cite this

Interference with S and G2 phase progression by polyamine synthesis inhibitors. / Heby, O.; Andersson, G.; Gray, Joe.

In: Experimental Cell Research, Vol. 111, No. 2, 1978, p. 461-464.

Research output: Contribution to journalArticle

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