Interactions between tumor cells and microenvironment in breast cancer: A new opportunity for targeted therapy

Shreya Mitra, Katherine Stemke-Hale, Gordon B. Mills, Sofie Claerhout

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Breast cancer remains the leading cause of morbidity and secondleading cause of death in women. Despite efforts to uncover new targeted therapies, a vast number of women diedue to refractory or recurrent breast tumors. Most breast cancer studies have focused on the intrinsic characteristics of breast tumor cells, including altered growth, proliferation, and metabolism. However, emerging research suggests that the tumor microenvironment can substantially affect relapse rates and therapeutic responses. In this review, we discuss the interactions between the tumor and microenvironment in breast cancer, with regardto mutational profiles and altered metabolism that could serve as potential therapeutic targets. We also describe current technologies available to study these interactions.

Original languageEnglish (US)
Pages (from-to)400-407
Number of pages8
JournalCancer Science
Volume103
Issue number3
DOIs
StatePublished - 2012
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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