Interactions between tumor cells and microenvironment in breast cancer: A new opportunity for targeted therapy

Shreya Mitra, Katherine Stemke-Hale, Gordon B. Mills, Sofie Claerhout

    Research output: Contribution to journalReview article

    12 Scopus citations


    Breast cancer remains the leading cause of morbidity and secondleading cause of death in women. Despite efforts to uncover new targeted therapies, a vast number of women diedue to refractory or recurrent breast tumors. Most breast cancer studies have focused on the intrinsic characteristics of breast tumor cells, including altered growth, proliferation, and metabolism. However, emerging research suggests that the tumor microenvironment can substantially affect relapse rates and therapeutic responses. In this review, we discuss the interactions between the tumor and microenvironment in breast cancer, with regardto mutational profiles and altered metabolism that could serve as potential therapeutic targets. We also describe current technologies available to study these interactions.

    Original languageEnglish (US)
    Pages (from-to)400-407
    Number of pages8
    JournalCancer Science
    Issue number3
    StatePublished - Jan 31 2012


    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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