Interactions between lymphocytes and myeloid cells regulate pro-versus anti-tumor immunity

David G. DeNardo, Pauline Andreu, Lisa Coussens

Research output: Contribution to journalArticle

271 Citations (Scopus)

Abstract

Tumor-associated myeloid cells have been implicated in regulating many of the "hallmarks of cancer" and thus fostering solid tumor development and metastasis. However, the same innate leukocytes also participate in anti-tumor immunity and restraint of malignant disease. While many factors regulate the propensity of myeloid cells to promote or repress cancerous growths, polarized adaptive immune responses by B and T lymphocytes have been identified as regulators of many aspects of myeloid cell biology by specifically regulating their functional capabilities. Here, we detail the diversity of heterogeneous B and T lymphocyte populations and their impacts on solid tumor development through their abilities to regulate myeloid cell function in solid tumors.

Original languageEnglish (US)
Pages (from-to)309-316
Number of pages8
JournalCancer and Metastasis Reviews
Volume29
Issue number2
DOIs
StatePublished - Jun 2010
Externally publishedYes

Fingerprint

Myeloid Cells
Immunity
Lymphocytes
Neoplasms
B-Lymphocytes
T-Lymphocytes
Foster Home Care
Adaptive Immunity
Cell Biology
Leukocytes
Neoplasm Metastasis
Growth
Population

Keywords

  • Cancer
  • Inflammation
  • Lymphocyte
  • Macrophage
  • Metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Interactions between lymphocytes and myeloid cells regulate pro-versus anti-tumor immunity. / DeNardo, David G.; Andreu, Pauline; Coussens, Lisa.

In: Cancer and Metastasis Reviews, Vol. 29, No. 2, 06.2010, p. 309-316.

Research output: Contribution to journalArticle

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