Interactions between endothelial cells and leukocytes

E. C. Butcher, David Lewinsohn, A. Duijvestijn, R. Bargatze, N. Wu, S. Jalkanen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We present evidence that specific receptors are utilized by neutrophils to control their interaction with endothelial cells at sites of acute inflammation and that these receptors are related if not identical to lymphocyte 'homing receptors' for lymphoid tissue high endothelium. We speculate that such receptors play a fundamental but not exclusive role in controlling the extravasation and tissue localization of all bone marrow-derived nucleated cells. In additon, we emphasize the active role of endothelial cells in the process of lymphocyte migration and leukocyte extravasation. By the expression of as yet unidentified organ-specific determinants for lymphocyte recognition, endothelial cells control the exit of particular lymphocyte subsets into mucosal versus nonmucosal sites, thus helping to determine the unique features of mucosal versus nonmucosal immune responses. Furthermore, we argue that endothelial cells are exquisitely responsive to local immune reactivity and present evidence that specific lymphokines, including γ-interferon, play an important role in inducing postcapillary venules to express differentiated features required for the support of lymphocyte traffic into lymphoid organs and into sites of chronic inflammation. Leukocytes, endothelial cells, and probably other tissue cell classes appear to interact at multiple levels by a varity of mechanisms to regulate the local extravasation of immune effector cells.

Original languageEnglish (US)
Pages (from-to)121-131
Number of pages11
JournalJournal of Cellular Biochemistry
Volume30
Issue number2
StatePublished - 1986
Externally publishedYes

Fingerprint

Endothelial cells
Lymphocytes
Leukocytes
Endothelial Cells
Tissue
Lymphocyte Homing Receptors
Inflammation
Venules
Lymphokines
Lymphocyte Subsets
Lymphoid Tissue
Interferons
Endothelium
Bone
Neutrophils
Bone Marrow

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Butcher, E. C., Lewinsohn, D., Duijvestijn, A., Bargatze, R., Wu, N., & Jalkanen, S. (1986). Interactions between endothelial cells and leukocytes. Journal of Cellular Biochemistry, 30(2), 121-131.

Interactions between endothelial cells and leukocytes. / Butcher, E. C.; Lewinsohn, David; Duijvestijn, A.; Bargatze, R.; Wu, N.; Jalkanen, S.

In: Journal of Cellular Biochemistry, Vol. 30, No. 2, 1986, p. 121-131.

Research output: Contribution to journalArticle

Butcher, EC, Lewinsohn, D, Duijvestijn, A, Bargatze, R, Wu, N & Jalkanen, S 1986, 'Interactions between endothelial cells and leukocytes', Journal of Cellular Biochemistry, vol. 30, no. 2, pp. 121-131.
Butcher EC, Lewinsohn D, Duijvestijn A, Bargatze R, Wu N, Jalkanen S. Interactions between endothelial cells and leukocytes. Journal of Cellular Biochemistry. 1986;30(2):121-131.
Butcher, E. C. ; Lewinsohn, David ; Duijvestijn, A. ; Bargatze, R. ; Wu, N. ; Jalkanen, S. / Interactions between endothelial cells and leukocytes. In: Journal of Cellular Biochemistry. 1986 ; Vol. 30, No. 2. pp. 121-131.
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