Interaction of epidermal growth factor with the hypothalamic-pituitary-adrenal axis: Potential physiologic relevance

A. Luger, A. E. Calogero, K. Kalogeras, W. T. Gallucci, P. W. Gold, Donald (Lynn) Loriaux, G. P. Chrousos

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Epidermal growth factor (EGF), a polypeptide mitogen that participates in wound healing, has ACTH-like activity in ewes. We examined its effects on the primate hypothalamic-pituitary-adrenal (HPA) axis by administering mouse EGF (mEGF) iv (0-100 μg/kg) to rhesus monkeys. mEGF caused dose-dependent elevations of plasma ACTH and cortisol in these animals. To define whether the locus of stimulation was the hypothalamus and/or the pituitary gland we examined the capacity of mEGF to directly stimulate hypothalamic CRH or pituitary ACTH secretion in a rat hypothalamic organ culture system and a rat pituitary cell system, respectively. mEGF stimulated hypothalamic CRH release in a dose-dependent manner, but failed to cause pituitary ACTH release. We conclude that EGF is a stimulator of the HPA axis in primates. Thus, EGF, and/or one of its naturally occurring analogs, may participate in the physiological activation of the HPA axis at times during which the concentrations of these factors are raised in the systemic circulation and/or locally in the hypothalamus. Such states may include trauma, surgery, and possibly emotional stress.

Original languageEnglish (US)
Pages (from-to)334-337
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume66
Issue number2
StatePublished - 1988
Externally publishedYes

Fingerprint

Epidermal Growth Factor
Adrenocorticotropic Hormone
Primates
Hypothalamus
Rats
Organ Culture Techniques
Pituitary Gland
Macaca mulatta
Mitogens
Psychological Stress
Wound Healing
Surgery
Hydrocortisone
Animals
Chemical activation
Plasmas
Peptides
Wounds and Injuries

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Interaction of epidermal growth factor with the hypothalamic-pituitary-adrenal axis : Potential physiologic relevance. / Luger, A.; Calogero, A. E.; Kalogeras, K.; Gallucci, W. T.; Gold, P. W.; Loriaux, Donald (Lynn); Chrousos, G. P.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 66, No. 2, 1988, p. 334-337.

Research output: Contribution to journalArticle

Luger, A. ; Calogero, A. E. ; Kalogeras, K. ; Gallucci, W. T. ; Gold, P. W. ; Loriaux, Donald (Lynn) ; Chrousos, G. P. / Interaction of epidermal growth factor with the hypothalamic-pituitary-adrenal axis : Potential physiologic relevance. In: Journal of Clinical Endocrinology and Metabolism. 1988 ; Vol. 66, No. 2. pp. 334-337.
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