Interaction of antibiotic lasalocid A (X537A) with praseodymium(III) in methanol

Shuenn tzong Chen, Charles Jr Springer

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The binding of lasalocid A (X537A) to Pr(III) in methanol has been studied by lasalocid fluorescence, circular dichtoism, and 1H and 13C NMR spectroscopy. It is clear that in addition to a mono complex, bis and tris complexes are also formed. Values of the binding constants and spectral properties of the various complexes have been determined by computer fitting of the binding isotherms. The Pr(III) ion binds only at the salicylic "head" of the lasalocid A, in stark contrast with other known structures. The lasalocid A appears to have an "open" conformation in these complexes. The relevance of these results to the structure and conformation of the Ca(II) complex is discussed. The first order rate constant for the dissociation of the tris complex has also been determined.

Original languageEnglish (US)
Pages (from-to)101-122
Number of pages22
JournalBioinorganic Chemistry
Volume9
Issue number2
DOIs
StatePublished - 1978
Externally publishedYes

Fingerprint

Praseodymium
Lasalocid
Methanol
Anti-Bacterial Agents
Conformations
Nuclear magnetic resonance spectroscopy
Isotherms
Rate constants
Magnetic Resonance Spectroscopy
Fluorescence
Head
Ions

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)

Cite this

Interaction of antibiotic lasalocid A (X537A) with praseodymium(III) in methanol. / Chen, Shuenn tzong; Springer, Charles Jr.

In: Bioinorganic Chemistry, Vol. 9, No. 2, 1978, p. 101-122.

Research output: Contribution to journalArticle

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