Intensive dose ifosfamide and etoposide with G-CSF for stem cell mobilization in patients with non-Hodgkin's lymphoma

M. L. Donato, R. E. Champlin, K. W. Van Besien, M. Korbling, F. Cabanillas, P. Anderlini, J. G. Gajewski, J. Lauppe, A. Durett, B. Andersson, S. Giralt, I. Khouri, F. Hagemeister, J. E. Romaguera, A. Sarris, P. McLaughlin, A. Younes, C. Ippoliti, D. A. Blamble, J. HesterA. Gee, M. A. Rodriguez

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    Abstract

    We studied 36 patients with non-Hodgkin's lymphoma to evaluate the stem cell yield following recovery from intensive dose ifosfamide and etoposide given as mobilization chemotherapy. We also assessed the toxicity of the regimen and engraftment kinetics. All patients had intermediate grade lymphoma and had either failed to achieve a complete remission to induction chemotherapy or had relapsed. Patients received ifosfamide 10 g/m2 IV total dose given over 72 hours, etoposide 150 mg/m2 IV every 12 hours for 6 doses and G-CSF 10 μg/kg/d. Thirty-four patients went on to receive high-dose chemotherapy with BEAM or with CVP and BEAM. A median of 2 (1-10) apheresis was required to reach the target CD34+ count of > 4 x 106/kg. A median of 13.1 CD34+ cells/kg (4.1-148) was obtained. Toxicity was limited to mucositis in 3 patients, transient confusion and transient rise in liver function tests in 3 and 2 patients respectively. The median time to engraftment was 10 days (8-17) for all the patients undergoing high-dose chemotherapy. The regimen of intensive dose ifosfamide and etoposide along with G-CSF is well tolerated and in this group of patients has lead to successful stem cell harvests and sustained engraftment.

    Original languageEnglish (US)
    Pages (from-to)317-324
    Number of pages8
    JournalLeukemia and Lymphoma
    Volume35
    Issue number3-4
    DOIs
    StatePublished - Jan 1 1999

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    Keywords

    • Etoposide stem cells
    • Ifosfamide
    • Lymphoma
    • Mobilization

    ASJC Scopus subject areas

    • Hematology
    • Oncology
    • Cancer Research

    Cite this

    Donato, M. L., Champlin, R. E., Van Besien, K. W., Korbling, M., Cabanillas, F., Anderlini, P., Gajewski, J. G., Lauppe, J., Durett, A., Andersson, B., Giralt, S., Khouri, I., Hagemeister, F., Romaguera, J. E., Sarris, A., McLaughlin, P., Younes, A., Ippoliti, C., Blamble, D. A., ... Rodriguez, M. A. (1999). Intensive dose ifosfamide and etoposide with G-CSF for stem cell mobilization in patients with non-Hodgkin's lymphoma. Leukemia and Lymphoma, 35(3-4), 317-324. https://doi.org/10.3109/10428199909145736