Intensity-based modified Doppler variance algorithm

Application to phase instable and phase stable optical coherence tomography systems

Gangjun Liu, Lidek Chou, Wangcun Jia, Wenjuan Qi, Bernard Choi, Zhongping Chen

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The traditional phase-resolved Doppler method demonstrates great success for in-vivo imaging of blood flow and blood vessels. However, the phase-resolved method always requires high phase stability of the system. In phase instable situations, the performance of the phase-resolved methods will be degraded. We propose a modified Doppler variance algorithm that is based on the intensity or amplitude value. Performances of the proposed algorithm are compared with traditional phase-resolved Doppler variance and color Doppler methods for both phase stable and phase instable systems. For the phase instable situation, the proposed algorithm demonstrates images without phase instability induced artifacts. In-vivo imaging of window-chamber hamster skin is demonstrated for phase instable situation with a spectrometer-based Fourier domain OCT system. A microelectromechanical systems (MEMS) based swept source OCT (SSOCT) system is also used to demonstrate the performance of the proposed method in a phase instable situation. The phase stability of the SSOCT system is analyzed. In-vivo imaging of the blood vessel of human skin is demonstrated with the proposed method and the SSOCT system. For the phase stable situation, the proposed algorithm also demonstrates comparable performance with traditional phase-resolved methods. In-vivo imaging of the human choroidal blood vessel network is demonstrated with the proposed method under the phase stable situation. Depth-resolved fine choroidal blood vessel networks are shown.

Original languageEnglish (US)
Pages (from-to)11429-11440
Number of pages12
JournalOptics Express
Volume19
Issue number12
StatePublished - Jun 6 2011
Externally publishedYes

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blood vessels
tomography
hamsters
blood flow
microelectromechanical systems
vessels
artifacts
chambers
spectrometers
color

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Intensity-based modified Doppler variance algorithm : Application to phase instable and phase stable optical coherence tomography systems. / Liu, Gangjun; Chou, Lidek; Jia, Wangcun; Qi, Wenjuan; Choi, Bernard; Chen, Zhongping.

In: Optics Express, Vol. 19, No. 12, 06.06.2011, p. 11429-11440.

Research output: Contribution to journalArticle

Liu, Gangjun ; Chou, Lidek ; Jia, Wangcun ; Qi, Wenjuan ; Choi, Bernard ; Chen, Zhongping. / Intensity-based modified Doppler variance algorithm : Application to phase instable and phase stable optical coherence tomography systems. In: Optics Express. 2011 ; Vol. 19, No. 12. pp. 11429-11440.
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