Integration of the regulation of reproductive function and energy balance: Lactation as a model

M (Susan) Smith, Kevin Grove

    Research output: Contribution to journalArticle

    142 Citations (Scopus)

    Abstract

    Lactation is a physiological model for studying how the hypothalamus integrates peripheral signals, such as sensory signals (suckling stimulus) and those denoting energy balance (leptin), to alter hypothalamic function regulating food intake/energy balance and reproduction. The characteristics of food intake/energy balance during lactation are extreme hyperphagia, coupled with negative energy balance. The arcuate nucleus Neuropeptide Y (ARH-NPY) system is activated by: (1) brainstem projections specifically activated by the suckling stimulus, and (2) the decrease in leptin in response to the metabolic drain of milk production. NPY neurons from the ARH make direct contact with GnRH neurons and with CRH neurons in the PVH. NPY neurons also make contact with orexin and MCH neurons in the LHA, which, in turn, make contacts with GnRH neurons. Thus, the ARH-NPY system provides a neuroanatomical framework by which to integrate changes in food intake/energy with the regulation of cyclic reproductive function.

    Original languageEnglish (US)
    Pages (from-to)225-256
    Number of pages32
    JournalFrontiers in Neuroendocrinology
    Volume23
    Issue number3
    DOIs
    StatePublished - 2002

    Fingerprint

    Lactation
    Neurons
    Eating
    Leptin
    Gonadotropin-Releasing Hormone
    Hyperphagia
    Arcuate Nucleus of Hypothalamus
    Neuropeptide Y
    Hypothalamus
    Brain Stem
    Reproduction
    Milk

    ASJC Scopus subject areas

    • Endocrine and Autonomic Systems
    • Endocrinology, Diabetes and Metabolism

    Cite this

    Integration of the regulation of reproductive function and energy balance : Lactation as a model. / Smith, M (Susan); Grove, Kevin.

    In: Frontiers in Neuroendocrinology, Vol. 23, No. 3, 2002, p. 225-256.

    Research output: Contribution to journalArticle

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