TY - JOUR
T1 - Integration of the regulation of reproductive function and energy balance
T2 - Lactation as a model
AU - Smith, M. Susan
AU - Grove, Kevin L.
N1 - Funding Information:
We express our thanks to Drs. Chien Li and Rebecca Brogan for their work that was conducted in our laboratory and discussed in this chapter. We also thank Peilin Chen, Rebecca Campbell, Dr. Patricia Williamson, Dr. Xiao Qui Xiao, and Bernadette Grayson for their ongoing work that was discussed in this chapter and their critical appraisal of the manuscript. This work was supported by U.S. Public Health Service Grants HD14643, RR00163, and HD08373.
PY - 2002
Y1 - 2002
N2 - Lactation is a physiological model for studying how the hypothalamus integrates peripheral signals, such as sensory signals (suckling stimulus) and those denoting energy balance (leptin), to alter hypothalamic function regulating food intake/energy balance and reproduction. The characteristics of food intake/energy balance during lactation are extreme hyperphagia, coupled with negative energy balance. The arcuate nucleus Neuropeptide Y (ARH-NPY) system is activated by: (1) brainstem projections specifically activated by the suckling stimulus, and (2) the decrease in leptin in response to the metabolic drain of milk production. NPY neurons from the ARH make direct contact with GnRH neurons and with CRH neurons in the PVH. NPY neurons also make contact with orexin and MCH neurons in the LHA, which, in turn, make contacts with GnRH neurons. Thus, the ARH-NPY system provides a neuroanatomical framework by which to integrate changes in food intake/energy with the regulation of cyclic reproductive function.
AB - Lactation is a physiological model for studying how the hypothalamus integrates peripheral signals, such as sensory signals (suckling stimulus) and those denoting energy balance (leptin), to alter hypothalamic function regulating food intake/energy balance and reproduction. The characteristics of food intake/energy balance during lactation are extreme hyperphagia, coupled with negative energy balance. The arcuate nucleus Neuropeptide Y (ARH-NPY) system is activated by: (1) brainstem projections specifically activated by the suckling stimulus, and (2) the decrease in leptin in response to the metabolic drain of milk production. NPY neurons from the ARH make direct contact with GnRH neurons and with CRH neurons in the PVH. NPY neurons also make contact with orexin and MCH neurons in the LHA, which, in turn, make contacts with GnRH neurons. Thus, the ARH-NPY system provides a neuroanatomical framework by which to integrate changes in food intake/energy with the regulation of cyclic reproductive function.
UR - http://www.scopus.com/inward/record.url?scp=0036334426&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036334426&partnerID=8YFLogxK
U2 - 10.1016/S0091-3022(02)00002-X
DO - 10.1016/S0091-3022(02)00002-X
M3 - Article
C2 - 12127305
AN - SCOPUS:0036334426
SN - 0091-3022
VL - 23
SP - 225
EP - 256
JO - Frontiers in Neuroendocrinology
JF - Frontiers in Neuroendocrinology
IS - 3
ER -