Integration of npy, agrp, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat

Michael A. Cowley, Nina Pronchuk, Wei Fan, Daniela M. Dinulescu, William F. Colmers, Roger D. Cone

Research output: Contribution to journalArticle

475 Citations (Scopus)

Abstract

Energy stores are held relatively constant in many mammals. The circuitry necessary for maintaining energy homeostasis should (1) sense the amount of energy stored in adipose tissue, (2) sense and integrate the multiple opposing signals regarding nutritional state, and (3) provide output regulating energy intake and expenditure to maintain energy homeostasis. We demonstrate that individual neurons within the paraventricular nucleus of the hypothalamus (PVH) are capable of detection and integration of orexigenic (neuropeptide Y [NPY]) and anorexigenic (melanocortin) signals, that NPY and melanocortins are functional antagonists of each other within the PVH in the regulation of feeding behavior, and that melanocortin administration within the PVH regulates both feeding behavior and energy expenditure. These data provide a cellular basis for the adipostat within neurons in the PVH that appear to be jointly regulated by NPY- and melanocortin-responsive neurons.

Original languageEnglish (US)
Pages (from-to)155-163
Number of pages9
JournalNeuron
Volume24
Issue number1
DOIs
StatePublished - Sep 1999

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Melanocortins
Paraventricular Hypothalamic Nucleus
Hypothalamus
Neuropeptide Y
Feeding Behavior
Neurons
Energy Metabolism
Homeostasis
Energy Intake
Adipose Tissue
Mammals
3-nitro-2-pyridinesulfenyl

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Integration of npy, agrp, and melanocortin signals in the hypothalamic paraventricular nucleus : Evidence of a cellular basis for the adipostat. / Cowley, Michael A.; Pronchuk, Nina; Fan, Wei; Dinulescu, Daniela M.; Colmers, William F.; Cone, Roger D.

In: Neuron, Vol. 24, No. 1, 09.1999, p. 155-163.

Research output: Contribution to journalArticle

Cowley, Michael A. ; Pronchuk, Nina ; Fan, Wei ; Dinulescu, Daniela M. ; Colmers, William F. ; Cone, Roger D. / Integration of npy, agrp, and melanocortin signals in the hypothalamic paraventricular nucleus : Evidence of a cellular basis for the adipostat. In: Neuron. 1999 ; Vol. 24, No. 1. pp. 155-163.
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