Integrating phenotype ontologies across multiple species

Christopher J. Mungall, Georgios V. Gkoutos, Cynthia L. Smith, Melissa Haendel, Suzanna E. Lewis, Michael Ashburner

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

Phenotype ontologies are typically constructed to serve the needs of a particular community, such as annotation of genotype-phenotype associations in mouse or human. Here we demonstrate how these ontologies can be improved through assignment of logical definitions using a core ontology of phenotypic qualities and multiple additional ontologies from the Open Biological Ontologies library. We also show how these logical definitions can be used for data integration when combined with a unified multi-species anatomy ontology.

Original languageEnglish (US)
Article numberr2
JournalGenome Biology
Volume11
Issue number1
DOIs
StatePublished - Jan 8 2010
Externally publishedYes

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Biological Ontologies
Genetic Association Studies
Libraries
phenotype
Anatomy
Phenotype
mice
anatomy
genotype
genotype-phenotype correlation

ASJC Scopus subject areas

  • Genetics
  • Cell Biology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Mungall, C. J., Gkoutos, G. V., Smith, C. L., Haendel, M., Lewis, S. E., & Ashburner, M. (2010). Integrating phenotype ontologies across multiple species. Genome Biology, 11(1), [r2]. https://doi.org/10.1186/gb-2010-11-1-r2

Integrating phenotype ontologies across multiple species. / Mungall, Christopher J.; Gkoutos, Georgios V.; Smith, Cynthia L.; Haendel, Melissa; Lewis, Suzanna E.; Ashburner, Michael.

In: Genome Biology, Vol. 11, No. 1, r2, 08.01.2010.

Research output: Contribution to journalArticle

Mungall, CJ, Gkoutos, GV, Smith, CL, Haendel, M, Lewis, SE & Ashburner, M 2010, 'Integrating phenotype ontologies across multiple species', Genome Biology, vol. 11, no. 1, r2. https://doi.org/10.1186/gb-2010-11-1-r2
Mungall CJ, Gkoutos GV, Smith CL, Haendel M, Lewis SE, Ashburner M. Integrating phenotype ontologies across multiple species. Genome Biology. 2010 Jan 8;11(1). r2. https://doi.org/10.1186/gb-2010-11-1-r2
Mungall, Christopher J. ; Gkoutos, Georgios V. ; Smith, Cynthia L. ; Haendel, Melissa ; Lewis, Suzanna E. ; Ashburner, Michael. / Integrating phenotype ontologies across multiple species. In: Genome Biology. 2010 ; Vol. 11, No. 1.
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