Integrating nanomedicine into clinical radiotherapy regimens

Allison N. DuRoss; Megan J. Neufeld; Shushan Rana; Charles R. Thomas; Conroy Sun

doi:10.1016/j.addr.2019.07.002

Integrating nanomedicine into clinical radiotherapy regimens

Allison N. DuRoss, Megan J. Neufeld, Shushan Rana, Charles R. Thomas, Conroy Sun

Radiation Medicine

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

While the advancement of clinical radiotherapy was driven by technological innovations throughout the 20th century, continued improvement relies on rational combination therapies derived from biological insights. In this review, we highlight the importance of combination radiotherapy in the era of precision medicine. Specifically, we survey and summarize the areas of research where improved understanding in cancer biology will propel the field of radiotherapy forward by allowing integration of novel nanotechnology-based treatments.

Original language	English (US)
Pages (from-to)	35-56
Number of pages	22
Journal	Advanced Drug Delivery Reviews
Volume	144
DOIs	https://doi.org/10.1016/j.addr.2019.07.002
State	Published - Apr 2019

Keywords

Cancer
Chemoradiotherapy
Dosing
Drug delivery
Multimodal therapy
Nanoparticles
Radiation therapy

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.addr.2019.07.002

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title = "Integrating nanomedicine into clinical radiotherapy regimens",

abstract = "While the advancement of clinical radiotherapy was driven by technological innovations throughout the 20th century, continued improvement relies on rational combination therapies derived from biological insights. In this review, we highlight the importance of combination radiotherapy in the era of precision medicine. Specifically, we survey and summarize the areas of research where improved understanding in cancer biology will propel the field of radiotherapy forward by allowing integration of novel nanotechnology-based treatments.",

keywords = "Cancer, Chemoradiotherapy, Dosing, Drug delivery, Multimodal therapy, Nanoparticles, Radiation therapy",

author = "DuRoss, {Allison N.} and Neufeld, {Megan J.} and Shushan Rana and Thomas, {Charles R.} and Conroy Sun",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = apr,

doi = "10.1016/j.addr.2019.07.002",

language = "English (US)",

volume = "144",

pages = "35--56",

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T1 - Integrating nanomedicine into clinical radiotherapy regimens

AU - DuRoss, Allison N.

AU - Neufeld, Megan J.

AU - Rana, Shushan

AU - Thomas, Charles R.

AU - Sun, Conroy

PY - 2019/4

Y1 - 2019/4

N2 - While the advancement of clinical radiotherapy was driven by technological innovations throughout the 20th century, continued improvement relies on rational combination therapies derived from biological insights. In this review, we highlight the importance of combination radiotherapy in the era of precision medicine. Specifically, we survey and summarize the areas of research where improved understanding in cancer biology will propel the field of radiotherapy forward by allowing integration of novel nanotechnology-based treatments.

AB - While the advancement of clinical radiotherapy was driven by technological innovations throughout the 20th century, continued improvement relies on rational combination therapies derived from biological insights. In this review, we highlight the importance of combination radiotherapy in the era of precision medicine. Specifically, we survey and summarize the areas of research where improved understanding in cancer biology will propel the field of radiotherapy forward by allowing integration of novel nanotechnology-based treatments.

KW - Cancer

KW - Chemoradiotherapy

KW - Dosing

KW - Drug delivery

KW - Multimodal therapy

KW - Nanoparticles

KW - Radiation therapy

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UR - http://www.scopus.com/inward/citedby.url?scp=85068572676&partnerID=8YFLogxK

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DO - 10.1016/j.addr.2019.07.002

M3 - Review article

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AN - SCOPUS:85068572676

SN - 0169-409X

VL - 144

SP - 35

EP - 56

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

ER -

Integrating nanomedicine into clinical radiotherapy regimens

Abstract

Keywords

ASJC Scopus subject areas

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