Abstract
Client language (change talk [CT] and counterchange talk [CCT]) is gaining increasing support as an active ingredient of psychosocial interventions. Preliminary work with adults suggests that there may be a neural basis for this. With a diverse sample of adolescent cannabis users, we evaluated the influence of CT and CCT on blood oxygen level dependent (BOLD) response during an fMRI cannabis cue-exposure paradigm. We also investigated how BOLD activation related to treatment outcomes. Adolescent cannabis users (N = 43; 83.7% male; 53.5% Hispanic; M age = 16 years) were presented with CT and CCT derived from their prescan intervention session during the fMRI paradigm. Additionally, BOLD activation during CT (vs. CCT) was tested as a predictor of 1-month follow-up cannabis use behavior (frequency of cannabis use, cannabis problems, cannabis dependence). We observed a significant interaction, with greater activation during CT (vs. CCT) during the cannabis (but not control) cues in several areas key to self-referential processes (uncorrected p <0.001; medial frontal gyrus, insula). Furthermore, BOLD activation during CT (vs. CCT) during cannabis (but not control) cues in areas that underlie introspection (posterior cingulate, precuneus) was significantly related to youths' 1-month follow-up cannabis use behavior (frequency of cannabis use, cannabis problems, cannabis dependence; uncorrected p <0.001). These data indicate a unique interaction pattern, whereby CT (vs. CCT) during the cannabis (but not control) cues was associated with significantly greater activation in brain areas involved in introspection. Further, this activation was related to significantly better treatment outcomes for youth.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 510-525 |
| Number of pages | 16 |
| Journal | Psychology of Addictive Behaviors |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2013 |
| Externally published | Yes |
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Keywords
- Adolescents
- Cannabis
- Client language
- fMRI
- Motivational interviewing
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
- Medicine (miscellaneous)
Cite this
Integrating brain and behavior : Evaluating adolescents' response to a cannabis intervention. / Feldstein Ewing, Sarah; McEachern, Amber D.; Yezhuvath, Uma; Bryan, Angela D.; Hutchison, Kent E.; Filbey, Francesca M.
In: Psychology of Addictive Behaviors, Vol. 27, No. 2, 06.2013, p. 510-525.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Integrating brain and behavior
T2 - Evaluating adolescents' response to a cannabis intervention
AU - Feldstein Ewing, Sarah
AU - McEachern, Amber D.
AU - Yezhuvath, Uma
AU - Bryan, Angela D.
AU - Hutchison, Kent E.
AU - Filbey, Francesca M.
PY - 2013/6
Y1 - 2013/6
N2 - Client language (change talk [CT] and counterchange talk [CCT]) is gaining increasing support as an active ingredient of psychosocial interventions. Preliminary work with adults suggests that there may be a neural basis for this. With a diverse sample of adolescent cannabis users, we evaluated the influence of CT and CCT on blood oxygen level dependent (BOLD) response during an fMRI cannabis cue-exposure paradigm. We also investigated how BOLD activation related to treatment outcomes. Adolescent cannabis users (N = 43; 83.7% male; 53.5% Hispanic; M age = 16 years) were presented with CT and CCT derived from their prescan intervention session during the fMRI paradigm. Additionally, BOLD activation during CT (vs. CCT) was tested as a predictor of 1-month follow-up cannabis use behavior (frequency of cannabis use, cannabis problems, cannabis dependence). We observed a significant interaction, with greater activation during CT (vs. CCT) during the cannabis (but not control) cues in several areas key to self-referential processes (uncorrected p <0.001; medial frontal gyrus, insula). Furthermore, BOLD activation during CT (vs. CCT) during cannabis (but not control) cues in areas that underlie introspection (posterior cingulate, precuneus) was significantly related to youths' 1-month follow-up cannabis use behavior (frequency of cannabis use, cannabis problems, cannabis dependence; uncorrected p <0.001). These data indicate a unique interaction pattern, whereby CT (vs. CCT) during the cannabis (but not control) cues was associated with significantly greater activation in brain areas involved in introspection. Further, this activation was related to significantly better treatment outcomes for youth.
AB - Client language (change talk [CT] and counterchange talk [CCT]) is gaining increasing support as an active ingredient of psychosocial interventions. Preliminary work with adults suggests that there may be a neural basis for this. With a diverse sample of adolescent cannabis users, we evaluated the influence of CT and CCT on blood oxygen level dependent (BOLD) response during an fMRI cannabis cue-exposure paradigm. We also investigated how BOLD activation related to treatment outcomes. Adolescent cannabis users (N = 43; 83.7% male; 53.5% Hispanic; M age = 16 years) were presented with CT and CCT derived from their prescan intervention session during the fMRI paradigm. Additionally, BOLD activation during CT (vs. CCT) was tested as a predictor of 1-month follow-up cannabis use behavior (frequency of cannabis use, cannabis problems, cannabis dependence). We observed a significant interaction, with greater activation during CT (vs. CCT) during the cannabis (but not control) cues in several areas key to self-referential processes (uncorrected p <0.001; medial frontal gyrus, insula). Furthermore, BOLD activation during CT (vs. CCT) during cannabis (but not control) cues in areas that underlie introspection (posterior cingulate, precuneus) was significantly related to youths' 1-month follow-up cannabis use behavior (frequency of cannabis use, cannabis problems, cannabis dependence; uncorrected p <0.001). These data indicate a unique interaction pattern, whereby CT (vs. CCT) during the cannabis (but not control) cues was associated with significantly greater activation in brain areas involved in introspection. Further, this activation was related to significantly better treatment outcomes for youth.
KW - Adolescents
KW - Cannabis
KW - Client language
KW - fMRI
KW - Motivational interviewing
UR - http://www.scopus.com/inward/record.url?scp=84887503542&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84887503542&partnerID=8YFLogxK
U2 - 10.1037/a0029767
DO - 10.1037/a0029767
M3 - Article
C2 - 22925010
AN - SCOPUS:84887503542
VL - 27
SP - 510
EP - 525
JO - Psychology of Addictive Behaviors
JF - Psychology of Addictive Behaviors
SN - 0893-164X
IS - 2
ER -