Integrating brain and behavior: Evaluating adolescents' response to a cannabis intervention

Sarah Feldstein Ewing, Amber D. McEachern, Uma Yezhuvath, Angela D. Bryan, Kent E. Hutchison, Francesca M. Filbey

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Client language (change talk [CT] and counterchange talk [CCT]) is gaining increasing support as an active ingredient of psychosocial interventions. Preliminary work with adults suggests that there may be a neural basis for this. With a diverse sample of adolescent cannabis users, we evaluated the influence of CT and CCT on blood oxygen level dependent (BOLD) response during an fMRI cannabis cue-exposure paradigm. We also investigated how BOLD activation related to treatment outcomes. Adolescent cannabis users (N = 43; 83.7% male; 53.5% Hispanic; M age = 16 years) were presented with CT and CCT derived from their prescan intervention session during the fMRI paradigm. Additionally, BOLD activation during CT (vs. CCT) was tested as a predictor of 1-month follow-up cannabis use behavior (frequency of cannabis use, cannabis problems, cannabis dependence). We observed a significant interaction, with greater activation during CT (vs. CCT) during the cannabis (but not control) cues in several areas key to self-referential processes (uncorrected p <0.001; medial frontal gyrus, insula). Furthermore, BOLD activation during CT (vs. CCT) during cannabis (but not control) cues in areas that underlie introspection (posterior cingulate, precuneus) was significantly related to youths' 1-month follow-up cannabis use behavior (frequency of cannabis use, cannabis problems, cannabis dependence; uncorrected p <0.001). These data indicate a unique interaction pattern, whereby CT (vs. CCT) during the cannabis (but not control) cues was associated with significantly greater activation in brain areas involved in introspection. Further, this activation was related to significantly better treatment outcomes for youth.

Original languageEnglish (US)
Pages (from-to)510-525
Number of pages16
JournalPsychology of Addictive Behaviors
Volume27
Issue number2
DOIs
StatePublished - Jun 2013
Externally publishedYes

Fingerprint

Adolescent Behavior
Cannabis
Brain
Cues
Marijuana Abuse
Oxygen
Magnetic Resonance Imaging
Parietal Lobe
Gyrus Cinguli
Prefrontal Cortex
Hispanic Americans
Language

Keywords

  • Adolescents
  • Cannabis
  • Client language
  • fMRI
  • Motivational interviewing

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology
  • Medicine (miscellaneous)

Cite this

Integrating brain and behavior : Evaluating adolescents' response to a cannabis intervention. / Feldstein Ewing, Sarah; McEachern, Amber D.; Yezhuvath, Uma; Bryan, Angela D.; Hutchison, Kent E.; Filbey, Francesca M.

In: Psychology of Addictive Behaviors, Vol. 27, No. 2, 06.2013, p. 510-525.

Research output: Contribution to journalArticle

Feldstein Ewing, Sarah ; McEachern, Amber D. ; Yezhuvath, Uma ; Bryan, Angela D. ; Hutchison, Kent E. ; Filbey, Francesca M. / Integrating brain and behavior : Evaluating adolescents' response to a cannabis intervention. In: Psychology of Addictive Behaviors. 2013 ; Vol. 27, No. 2. pp. 510-525.
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