Insulinlike growth factors and their receptors as growth regulators in normal physiology and pathologic states

Derek LeRoith, Martin Adamo, Haim Werner, Charles Roberts

Research output: Contribution to journalArticle

101 Scopus citations


Insulinlike growth factors (IGFs), their binding proteins, and receptors are expressed by many different tissues, suggesting that they may act as parts of an autocrine paracrine system in addition to having a classic endocrine role. Since these growth factors are essential for the normal growth and development of the organism, their altered rate of production in a number of important disease states results in severe growth alterations. These include nutritional deprivation, growth hormone deficiency, diabetes, and malignancy.

Original languageEnglish (US)
Pages (from-to)134-139
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number4
Publication statusPublished - 1991
Externally publishedYes


ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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