Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus

Dianne P. Figlewicz, Patricia Szot, Paige A. Israel, Christopher Payne, Daniel M. Dorsa

Research output: Contribution to journalArticle

110 Scopus citations

Abstract

Acute and chronic in vitro insulin treatment can inhibit the uptake of norepinephrine (NE) by adult rat brain synaptosomes and slices, fetal neuronal cultures, and PC12 cells. In the present study we tested whether chronic in vivo insulin treatment could alter the biosynthetic capacity of rat locus coeruleus neurons for the NE transporter protein (NET). Chronic third ventricular insulin treatment resulted in a suppression of NET mRNA to about one third of the level of vehicle-treated controls. Our findings suggests that insulin may play a regulatory role in the synthesis of this transporter, thereby modulating activity in CNS noradrenergic pathways.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalBrain research
Volume602
Issue number1
DOIs
StatePublished - Jan 29 1993

Keywords

  • Catecholamine
  • Insulin
  • Locus ceruleus
  • Norepinephrine transporter

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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