Insulin-like growth factors I and II in evaluation of growth retardation

Ron G. Rosenfeld, Darrell M. Wilson, Phillip D.K. Lee, Raymond L. Hintz

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215 Scopus citations


Plasma samples from 68 growth hormone (GH)-deficient children (provocative serum GH level <7 ng/ml), 44 normal short children, and 197 children with normal height were asseyed by specific radioimmunoassays for the somatomedin peptides, insulin-like growth factors (IGF)-I and -II. Eighteen percent of the GH-deficient children had IGF-I levels within the normal range for age, whereas 32% of normal short children had low IGF-I levels. Low IGF-II levels were found in 52% of GH-deficient children, but also in 35% of normal short children. However, only 4% of GH-deficient children had normal plasma levels of both IGF-I and IGF-II. Furthermore, only 0.5% of normal children and 11% of normal short children had low plasma levels of both IGF-I and IGF-II. We conclude that plasma levels of either IGF-I or IGF-II overlap in GH-deficient and normal short children, but that the combination of radioimmunoassays may permit better discrimination among normal, normal short, and GH-deficient children.

Original languageEnglish (US)
Pages (from-to)428-433
Number of pages6
JournalThe Journal of pediatrics
Issue number3
StatePublished - Sep 1986


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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