Insulin-Like Growth Factors and Their Receptors in Normal Physiology and Pathological States

Derek LeRoith, Charles T. Roberts

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The insulin-like growth factor system, which includes the IGFs, IGF-binding proteins and IGF receptors, plays an essential role in normal growth and development, as well as the cellular differentiation of a number of other important systems, including the reproductive and immune systems. IGF action has also been implicated in several pathological conditions, including tissue repair, malnutrition, diabetes and malignancy.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Volume6
Issue number3-4
DOIs
StatePublished - Jul 1993
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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