Insulin-like growth factors and cancer

D. LeRoith, R. Baserga, L. Helman, Charles Roberts

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.

Original languageEnglish (US)
Pages (from-to)54-59
Number of pages6
JournalAnnals of Internal Medicine
Volume122
Issue number1
StatePublished - 1995
Externally publishedYes

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Somatomedins
Neoplasms
Human Development
Growth and Development
Carrier Proteins
Neoplasm Metastasis
Peptides
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

LeRoith, D., Baserga, R., Helman, L., & Roberts, C. (1995). Insulin-like growth factors and cancer. Annals of Internal Medicine, 122(1), 54-59.

Insulin-like growth factors and cancer. / LeRoith, D.; Baserga, R.; Helman, L.; Roberts, Charles.

In: Annals of Internal Medicine, Vol. 122, No. 1, 1995, p. 54-59.

Research output: Contribution to journalArticle

LeRoith, D, Baserga, R, Helman, L & Roberts, C 1995, 'Insulin-like growth factors and cancer', Annals of Internal Medicine, vol. 122, no. 1, pp. 54-59.
LeRoith D, Baserga R, Helman L, Roberts C. Insulin-like growth factors and cancer. Annals of Internal Medicine. 1995;122(1):54-59.
LeRoith, D. ; Baserga, R. ; Helman, L. ; Roberts, Charles. / Insulin-like growth factors and cancer. In: Annals of Internal Medicine. 1995 ; Vol. 122, No. 1. pp. 54-59.
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