Insulin-like growth factors and cancer

Derek LeRoith, Renato Baserga, Lee Helman, Charles T. Roberts

    Research output: Contribution to journalArticle

    282 Scopus citations

    Abstract

    The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.

    Original languageEnglish (US)
    Pages (from-to)54-59
    Number of pages6
    JournalAnnals of internal medicine
    Volume122
    Issue number1
    DOIs
    StatePublished - Jan 1 1995

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    ASJC Scopus subject areas

    • Internal Medicine

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