Insulin-like growth factor-I in growth and metabolism

P. Backeljauw, P. Bang, D. B. Dunger, A. Juul, Y. Le Bouc, R. Rosenfeld

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Deficiency of insulin-like growth factor-I (IGF-I) results in growth failure. A variety of molecular defects have been found to underlie severe primary IGF-I deficiency (IGFD), in which serum IGF-I concentrations are substantially decreased and fail to respond to GH therapy. Identification of more patients with primary or secondary IGFD is likely with investigative and diagnostic progress, particularly in the assessment of

Original languageEnglish (US)
Pages (from-to)3-16
Number of pages14
JournalJournal of Pediatric Endocrinology and Metabolism
Volume23
Issue number1-2
DOIs
StatePublished - Jan 1 2010

Keywords

  • Growth
  • Igf-i deficiency
  • Insulin-like growth factor-i
  • Metabolism
  • Severe insulin resistance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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