Insulin-like growth factor i improves height in growth hormone insensitivity: Two years’ results

M. B. Ranke, M. O. Savage, P. G. Chatelain, M. A. Preece, R. G. Rosenfeld, W. F. Blum, P. Wilton

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Thirty-one patients with growth hormone insensitivity syndrome (GHIS) and 2 with GH gene deletion (age 11.2 (3.7–22.9) years; BA (GP) 8.2 years; height −6.5 ± 1.6 SDS) were recruited for the multicenter study. At birth, length was more retarded (−1.38 SDS) than weight (−0.56 SDS). The rhIGF-I dose was 40-120 μg/kg BW twice daily s.c. In 26 patients, first year HV increased from 3.9 ± 1.8 to 8.5 ± 2.1 cm/year (delta (d) HT SDS 0.8 ± 0.5). In 18 patients, second year HV was 6.4 ± 2.2 cm/year (dHT SDS 0.4 ± 0.5). There was normal progression of puberty. Mean progression of BA was 1.2 and 1.5 years/ year during the first and second year. There was no dose effect of IGF-I on growth. Weight-for-height index (WHI) and skinfold thickness were significantly correlated at start, 12 and 24 months (r = 0.83, 0.87 and 0.79). Changes in WHI were positively correlated with dHT SDS during the first and second year (r = 0.54, 0.56). Serum IGF-I rose, IGF-II decreased, and IGFBP-3 remained constant. Adverse events were (number of occasions): Headache (21) (early); hypoglycemia (13); papilloedema (1) (reversible); Bell’s palsy (1) (reversible); lipohypertrophy (7) (late); tonsillectomy/adenoidectomy (3) (late). The results show that there is effective long-term treatment of GHIS with systemically administered IGF-I and support the view that IGFBPs play an important role in the action of IGF-I.

Original languageEnglish (US)
Pages (from-to)253-264
Number of pages12
JournalHormone Research in Paediatrics
Volume44
Issue number6
DOIs
StatePublished - Jan 1 1995

Keywords

  • Growth hormone insensitivity
  • IGF-I
  • Therapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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    Ranke, M. B., Savage, M. O., Chatelain, P. G., Preece, M. A., Rosenfeld, R. G., Blum, W. F., & Wilton, P. (1995). Insulin-like growth factor i improves height in growth hormone insensitivity: Two years’ results. Hormone Research in Paediatrics, 44(6), 253-264. https://doi.org/10.1159/000184637