Insulin-like growth factor-I deficiency caused by a partial deletion of the IGF-I gene: Effects of rhIGF-I therapy

C. Camacho-Hubner, K. A. Woods, F. Miraki-Moud, A. Clark, M. O. Savage

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Insulin-like growth factor-I (IGF-I) is one of the most important regulator of growth. IGF-I deficiency is associated with prenatal and post- natal growth failure and may arise primarily as a result of GH receptor/post- receptor abnormalities or defects in the synthesis and transport of IGF-I. We have previously reported a 17.2 year-old boy with severe growth retardation and undetectable serum levels of IGF-I caused by a partial deletion of the IGF-I gene. This short review will concentrate on results of a recent study which examined the effects of rhlGF-I therapy on the GH-IGF system of this patient. Similar to healthy individuals, this patient had normal IGFBP-3 but elevated ALS levels. IGF-I treatment has improved linear growth and insulin sensitivity in this patient by restoring IGF-I levels and by normalizing circulating GH, IGFBPs and insulin levels.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalGrowth Hormone and IGF Research
Volume9
Issue numberSUPPL. B
DOIs
StatePublished - Jan 1 1999

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Keywords

  • ALS
  • IGF-Binding Proteins
  • IGF-I gene deletion
  • RhlGF-I

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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