Insulin-like growth factor-I deficiency caused by a partial deletion of the IGF-I gene

Effects of rhIGF-I therapy

C. Camacho-Hubner, Kathryn (Katie) Woods, F. Miraki-Moud, A. Clark, M. O. Savage

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Insulin-like growth factor-I (IGF-I) is one of the most important regulator of growth. IGF-I deficiency is associated with prenatal and post- natal growth failure and may arise primarily as a result of GH receptor/post- receptor abnormalities or defects in the synthesis and transport of IGF-I. We have previously reported a 17.2 year-old boy with severe growth retardation and undetectable serum levels of IGF-I caused by a partial deletion of the IGF-I gene. This short review will concentrate on results of a recent study which examined the effects of rhlGF-I therapy on the GH-IGF system of this patient. Similar to healthy individuals, this patient had normal IGFBP-3 but elevated ALS levels. IGF-I treatment has improved linear growth and insulin sensitivity in this patient by restoring IGF-I levels and by normalizing circulating GH, IGFBPs and insulin levels.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalGrowth Hormone and IGF Research
Volume9
Issue numberSUPPL. B
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Insulin-Like Growth Factor I
Genes
Growth
Therapeutics
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor Binding Protein 3
Insulin Resistance
Insulin-Like Growth Factor I Deficiency
Insulin
Serum

Keywords

  • ALS
  • IGF-Binding Proteins
  • IGF-I gene deletion
  • RhlGF-I

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Insulin-like growth factor-I deficiency caused by a partial deletion of the IGF-I gene : Effects of rhIGF-I therapy. / Camacho-Hubner, C.; Woods, Kathryn (Katie); Miraki-Moud, F.; Clark, A.; Savage, M. O.

In: Growth Hormone and IGF Research, Vol. 9, No. SUPPL. B, 1999, p. 47-52.

Research output: Contribution to journalArticle

Camacho-Hubner, C. ; Woods, Kathryn (Katie) ; Miraki-Moud, F. ; Clark, A. ; Savage, M. O. / Insulin-like growth factor-I deficiency caused by a partial deletion of the IGF-I gene : Effects of rhIGF-I therapy. In: Growth Hormone and IGF Research. 1999 ; Vol. 9, No. SUPPL. B. pp. 47-52.
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