Insulin-like growth factor i: A possible metabolic signal involved in the regulation of female puberty

Jill K. Hiney, Sergio R. Ojeda, W. Les Dees

Research output: Contribution to journalArticlepeer-review

186 Scopus citations

Abstract

In both rats and primates, including humans, serum levels of insulin-like growth factor I (IGF-I) increase during the onset of puberty, suggesting a role for IGF-I in this process. We examined the ability of IGF-I to affect the release of hypothalamic luteinizing hormone releasing hormone (LHRH) in prepubertal female rats. Our results indicate that IGF-I acts on the median eminence, which contains the highest density of type 1 IGF receptors in the brain, to elicit a dose-related increase in LHRH release. In this regard, a minimal effective dose of 10 ng/ml (p<0.05) and a maximal effective dose of 100 ng/ml (p <0.01) was observed. IGF-II and insulin were one order of magnitude less effective. The results demonstrate that IGF-I has the capability to act directly upon the median eminence to effect release of LHRH, thereby suggesting a role for IGF-I in facilitating peripubertal changes in LHRH release. Thus, IGF-I may represent one of the "metabolic signals' thought to be involved in the initiation of puberty.

Original languageEnglish (US)
Pages (from-to)420-423
Number of pages4
JournalNeuroendocrinology
Volume54
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

Keywords

  • Female puberty
  • Insulin-like growth factor I
  • Luteinizing hormone releasing hormone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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