Insulin-like growth factor gene expression during rat embryonic development

Peter Rotwein, Karen M. Pollock, Mark Watson, Jeffrey D. Milbrandt

    Research output: Contribution to journalArticlepeer-review

    98 Scopus citations


    The function of insulin-like growth factors I and II (IGF-I and IGF-II) in embryogenesis is unknown. To investigate the ontogeny of IGF gene expression during mammalian development we used a highly sensitive and specific solutionhybridization assay to determine the steady state levels of IGF mRNAs during midgestation in the rat. IGF-I mRNA can be detected as early as day 11 of embryonic development and rises 8.6-fold over the ensuing 48 h. By contrast IGF-II mRNA is relatively constant over days 11-14 of gestation. These observations suggest that both IGFs may play important roles in early fetal development.

    Original languageEnglish (US)
    Pages (from-to)2141-2144
    Number of pages4
    Issue number6
    StatePublished - Dec 1 1987

    ASJC Scopus subject areas

    • Endocrinology

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