Insulin-like growth factor gene expression during rat embryonic development

P. Rotwein, K. M. Pollock, M. Watson, J. D. Milbrandt

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

The function of insulin-like growth factors I and II (IGF-I and IGF-II) in embryogenesis is unknown. To investigate the ontogeny of IGF gene expression during mammalian development we used a highly sensitive and specific solution-hybridization assay to determine the steady state levels of IGF mRNAs during midgestation in the rat. IGF-I mRNA can be detected as early as day 11 of embryonic development and rises 8.6-fold over the ensuing 48 h. By contrast IGF-II mRNA is relatively constant over days 11-14 of gestation. These observations suggest that both IGFs may play important roles in early fetal development.

Original languageEnglish (US)
Pages (from-to)2141-2144
Number of pages4
JournalEndocrinology
Volume121
Issue number6
StatePublished - 1987
Externally publishedYes

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Insulin-Like Growth Factor II
Somatomedins
Insulin-Like Growth Factor I
Embryonic Development
Gene Expression
Messenger RNA
Fetal Development
Pregnancy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Rotwein, P., Pollock, K. M., Watson, M., & Milbrandt, J. D. (1987). Insulin-like growth factor gene expression during rat embryonic development. Endocrinology, 121(6), 2141-2144.

Insulin-like growth factor gene expression during rat embryonic development. / Rotwein, P.; Pollock, K. M.; Watson, M.; Milbrandt, J. D.

In: Endocrinology, Vol. 121, No. 6, 1987, p. 2141-2144.

Research output: Contribution to journalArticle

Rotwein, P, Pollock, KM, Watson, M & Milbrandt, JD 1987, 'Insulin-like growth factor gene expression during rat embryonic development', Endocrinology, vol. 121, no. 6, pp. 2141-2144.
Rotwein P, Pollock KM, Watson M, Milbrandt JD. Insulin-like growth factor gene expression during rat embryonic development. Endocrinology. 1987;121(6):2141-2144.
Rotwein, P. ; Pollock, K. M. ; Watson, M. ; Milbrandt, J. D. / Insulin-like growth factor gene expression during rat embryonic development. In: Endocrinology. 1987 ; Vol. 121, No. 6. pp. 2141-2144.
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