Insulin-like growth factor gene expression during rat embryonic development

Peter Rotwein, Karen M. Pollock, Mark Watson, Jeffrey D. Milbrandt

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

The function of insulin-like growth factors I and II (IGF-I and IGF-II) in embryogenesis is unknown. To investigate the ontogeny of IGF gene expression during mammalian development we used a highly sensitive and specific solutionhybridization assay to determine the steady state levels of IGF mRNAs during midgestation in the rat. IGF-I mRNA can be detected as early as day 11 of embryonic development and rises 8.6-fold over the ensuing 48 h. By contrast IGF-II mRNA is relatively constant over days 11-14 of gestation. These observations suggest that both IGFs may play important roles in early fetal development.

Original languageEnglish (US)
Pages (from-to)2141-2144
Number of pages4
JournalEndocrinology
Volume121
Issue number6
DOIs
StatePublished - Dec 1 1987

ASJC Scopus subject areas

  • Endocrinology

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    Rotwein, P., Pollock, K. M., Watson, M., & Milbrandt, J. D. (1987). Insulin-like growth factor gene expression during rat embryonic development. Endocrinology, 121(6), 2141-2144. https://doi.org/10.1210/endo-121-6-2141