Insulin-like growth factor binding protein-I levels are strongly associated with insulin sensitivity and obesity in early pubertal children

Sharon H. Travers, Jose I. Labarta, Sharron E. Gargosky, Ron G. Rosenfeld, Barrett W. Jeffers, Robert H. Eckel

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

In conditions associated with insulin resistance, insulin-like growth factor binding protein-I (IGFBP-I) levels have been shown to correlate inversely with insulin levels. Puberty is associated with insulin resistance and thus provides a model for comparing the relationship of IGFBP-I to both insulin levels and measures of insulin sensitivity. Our study population consisted of 104 healthy pubertal children, age 9.8-14.6 yr. Each subject had his/her insulin sensitivity (Si) assessed by the modified minimal model of Bergman, which employs a frequently sampled iv glucose tolerance test. Results showed that IGFBP-I levels were significantly higher in boys than in pubertally matched girls (P < 0.01). There was a strong positive correlation between IGFBP-I levels and Si (r = 0.65, P < 0.0001) and a weaker negative correlation with fasting insulin levels (r = -0.38, P < 0.0001). An inverse relationship was also found between IGFBP-I levels and body mass index (r = - 0.46, P < 0.0001) and with IGF-I levels (girls only, r = -0.41, P < 0.003). Consequently, insulin sensitivity, obesity, and IGF-I are important predictors of IGFBP-I levels in pubertal children. It is possible that insulin-mediated suppression of IGFBP-I in obese children may increase free IGF-I levels and thus contribute to somatic growth. The same mechanism may operate in pubertal children, where insulin resistance and growth acceleration occur simultaneously.

Original languageEnglish (US)
Pages (from-to)1935-1939
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume83
Issue number6
DOIs
StatePublished - Nov 11 1998

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Insulin-like growth factor binding protein-I levels are strongly associated with insulin sensitivity and obesity in early pubertal children'. Together they form a unique fingerprint.

  • Cite this